Evidence map›Paper›PMID 40788970›Full record

ArticlePLoS pathogens2025

A hypovirulence-associated capsidless bi-segmented ssRNA mycovirus enhances melanin and microsclerotial production in a vascular phytopathogenic fungus.

Jiamin Gao, Xuekun Zhang, Jichun Jia, Huang Huang, Jiasen Cheng, Yanping Fu, Xueqiong Xiao, Bo Li, Tao Chen, Xiao Yu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiamin GaoState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, China.
Xuekun ZhangKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, China.
Jichun JiaNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Huang HuangNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Jiasen ChengNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Yanping FuNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xueqiong XiaoNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Bo LiNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Tao ChenNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xiao YuNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Longfu ZhuHubei Hongshan Laboratory, Wuhan, China.
Tom HsiangEnvironmental Sciences, University of Guelph, Guelph, Ontario, Canada.
Daohong JiangNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Lili ZhangState Key Laboratory Incubation Base for Conservation and Utilization of Bio-Resource in Tarim Basin, College of Life Science and Technology, Tarim University, Alar, China.
Jiatao XieNational Key Laboratory of Agricultural Microbiology, The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-1961-0338

Funding

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaTarim University
6 · The paper itself

Abstract

Mycoviruses are increasingly recognized for their multifaceted roles in fungal ecology, because of advances in understanding of their biology and molecular features. In this research, we identified and characterized two capsidless, bi-segmented positive-sense RNA mycoviruses: Verticillium dahliae ormycovirus 1 (VdOMV1) and VdOMV2, both of which infect Verticillium dahliae, a fungal pathogen causing vascular wilt of cotton. Phylogenetic analysis revealed that VdOMV1 and VdOMV2 cluster within the ormycovirus group, an evolutionary lineage unique to Riboviria. VdOMV2 may significantly enhanced V. dahliae melanin production and microsclerotial formation through regulating melanin synthesis-associated genes. This mediated the conversion from production of hyphae to microsclerotia, and enhanced V. dahliae survival under adverse abiotic stress conditions. Furthermore, VdOMV2 boosted the penetration ability of hyphae through cellophane membranes, while inhibiting the proliferation of V. dahliae hyphae within plants, and negatively modulated genes related to pathogenicity, possibly conferring hypovirulence. Enhancements in penetration and survival not only increase the efficacy of hypovirulent strains in overcoming environmental challenges, but also highlight the potential of VdOMV2-infected strains for managing Verticillium wilt in agricultural settings, thus representing an alternative mycovirus-based biocontrol approach for vascular fungal diseases.

Indexed as

AscomycotaFungal VirusesMelaninsPlant DiseasesRNA VirusesHyphaePhylogenyVerticilliumVirulenceMelanins

Identifiers

PMID40788970
PMCPMC12360652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.