Evidence map›Paper›PMID 40789792›Full record

SynthesisMetabolomics : Official journal of the Metabolomic Society2025

Dysregulation of serum bile acids in liver cancer: a systematic review and meta-analysis.

Qing Peng, Liyuan Hao, Shenghao Li, Xiaoyu Hu

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qing Peng *Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Liyuan Hao *Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Shenghao LiClinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Xiaoyu HuDepartment of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, No.39, Shierqiao Road, Jinniu District, Chengdu, 610075, Sichuan, China. huxiaoyu1124@163.com.

Funding

National Natural Science Foundation of China 81973840
6 · The paper itself

Abstract

backgroundPrevious studies have indicated that certain bile acids (BAs) were associated with the occurrence and development of liver cancer. However, a comprehensive analysis of serum bile acid (BA) expression patterns and dysregulation in liver cancer remained unexplored. AIM OF REVIEW: This meta-analysis aimed to evaluate serum BA profiles comprehensively and determine the association between specific BA molecular species and liver cancer. KEY SCIENTIFIC CONCEPTS OF REVIEW: BAs, key molecules in metabolism and signaling, have been increasingly recognized for their role in liver cancer pathogenesis. While prior studies have explored individual BAs, a systematic analysis of their dysregulation in liver cancer has remained unaddressed. This meta-analysis analyzed data from 14 original studies with a total of 2994 participants (1686 liver cancer cases and 1308 controls) and revealed significant alterations in both primary and secondary BAs, along with disrupted BA ratios in liver cancer patients. These findings underscored the profound metabolic dysregulation in liver cancer and presented critical insights that might aid in disease diagnosis and management.

Indexed as

Bile Acids and SaltsLiver NeoplasmsHumansBile Acids and SaltsBile acidsLiver cancerMeta-analysisMetabolism

Identifiers

PMID40789792

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.