ArticleNature microbiology2025
Metabolic reprogramming enhances the susceptibility of multidrug- and carbapenem-resistant bacteria to antibiotics.
Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Glutamate Potentiates Meropenem Killing of Carbapenem-ResistantACS omega · 2026Article
- Phosphoenolpyruvate Carboxykinase ControlsBiology · 2026Article
- Metabolic adaptations in antibiotic-resistantMicrobiology spectrum · 2026Article
- Xylose-induced tricarboxylic acid cycle activation resensitizes gentamicin-resistantApplied and environmental microbiology · 2026Article
- Immunoprotective Effects of Mori Cortex Radicis Water Extract on Major Aquatic Pathogen (Life (Basel, Switzerland) · 2026Article
- Metabolic activation of pyruvate cycle by protocatechualdehyde triggers oxidative killing of ampicillin-resistantMicrobiology spectrum · 2026Article
- Screening of exogenous nutrients for pathogenic bacteria and development of highly active bactericides.mSystems · 2026Article
- Article
- Combating Bacterial Infection with Metabolism-Regulating Nanomaterials.International journal of nanomedicine · 2026Review
- Genome-wide screen reveals glycerol-induced aminoglycoside potentiation againstAntimicrobial agents and chemotherapy · 2025Article
- Exogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistantmSystems · 2025Article
- Integration host factor regulates antibiotic susceptibility through modulating alanine metabolism inFrontiers in microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Carbapenem-resistant Enterobacteriaceae and extended-spectrum β-lactamase-resistant bacterial pathogens are a major threat to human and global health. Alternative antibiotics are therefore used to treat infections caused by these pathogens, and approaches to increase their efficacy are needed. Here we used metabolomics, mutant Escherichia coli strains and whole-genome sequencing to examine the metabolic profiles of clinical carbapenem-resistant (CR-ECO), multidrug-resistant (MDR-ECO) and antibiotic-sensitive E. coli (S-ECO) isolates in response to antibiotics in vitro including micronomicin, an aminoglycoside. Downregulation of pyruvate formate-lyase (PFL) alters membrane permeability and reduces the efficacy of micronomicin, the most potent antibiotic, in CR-ECO and MDR-ECO. The metabolism of pyruvate to formate is required to potentiate the effects of micronomicin across multiple bacterial pathogens. Mice infected with CR-ECO and treated with formate plus micronomicin had reduced pathogen growth and spread, and increased survival, compared with mice treated with micronomicin or formate alone. Finally, elevated activity or expression of PFL and increased intracellular CO
Indexed as
Identifiers
40790107What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.