Evidence map›Paper›PMID 40790270›Full record

ArticleNature neuroscience2025

Potentiation of mitochondrial function by mitoDREADD-G

Antonio C Pagano Zottola, Rebeca Martín-Jiménez, Gianluca Lavanco, Geneviève Hamel-Côté, Carla Ramon-Duaso, Rui S Rodrigues, Yamuna Mariani, Mehtab Khan, Filippo Drago, Stephanie Jean and 24 more

Abstract read
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In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Antonio C Pagano Zottola *Endocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.ORCID http://orcid.org/0000-0001-9528-5448
Rebeca Martín-Jiménez *Canada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada.
Gianluca Lavanco *Endocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.ORCID http://orcid.org/0000-0002-4962-379X
Geneviève Hamel-Côté *Canada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada.ORCID http://orcid.org/0000-0002-2547-8516
Carla Ramon-DuasoHospital del Mar Medical Research Institute, PRBB, Barcelona, Spain.ORCID http://orcid.org/0000-0001-8358-4440
Rui S RodriguesEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.ORCID http://orcid.org/0000-0002-9343-745X
Yamuna MarianiEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Mehtab KhanCanada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada.
Filippo DragoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy.
Stephanie JeanCanada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada.
Itziar Bonilla-Del RíoLaboratory of Ultrastructural and Functional Neuroanatomy of the Synapse, Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.
Daniel Jimenez-BlascoInstitute of Functional Biology and Genomics (IBGF), Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-1384-1832
Jon Egaña-HuguetDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country/ 'Neuroglia basis of behavioral processes' Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Abel Eraso-PichotEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Sandra BeriainEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.ORCID http://orcid.org/0000-0002-9139-1646
Astrid CannichEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Laura Vidal-PalenciaHospital del Mar Medical Research Institute, PRBB, Barcelona, Spain.
Rosmara InfantinoEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Francisca Julio-KalajzićEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Doriane GisquetEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Ania GoncalvesUniversity of Bordeaux, Bordeaux, France.
Inas Al-YounisCanada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada.ORCID http://orcid.org/0000-0001-7834-0484
Yann BaussanCanada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada.
Stephane Duvezin-CaubetUniversity of Bordeaux, Bordeaux, France.
Anne DevinUniversity of Bordeaux, Bordeaux, France.
Edgar Soria-GomezDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country/ 'Neuroglia basis of behavioral processes' Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Nagore PuenteLaboratory of Ultrastructural and Functional Neuroanatomy of the Synapse, Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.
Juan P BolañosInstitute of Functional Biology and Genomics (IBGF), Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-3949-6862
Pedro GrandesLaboratory of Ultrastructural and Functional Neuroanatomy of the Synapse, Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.
Sandrine PouvreauEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France.
Arnau Busquets-GarciaHospital del Mar Medical Research Institute, PRBB, Barcelona, Spain.
Giovanni MarsicanoEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France. giovanni.marsicano@inserm.fr.ORCID http://orcid.org/0000-0003-3804-1951
Luigi BellocchioEndocannabinoids and Neuroadaptation U1215 NeuroCentre Magendie, INSERM, Bordeaux, France. luigi.bellocchio@inserm.fr.ORCID http://orcid.org/0000-0001-7774-3935
Etienne Hebert-ChatelainCanada Research Chair in Mitochondrial Signaling and Physiopathology, University of Moncton, Moncton, New Brunswick, Canada. Etienne.hebert.chatelain@umoncton.ca.ORCID http://orcid.org/0000-0003-1480-2787

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many brain disorders involve mitochondrial alterations, but owing to the lack of suitable tools, the causal role of mitochondrial dysfunction in pathophysiological processes is difficult to establish. Heterotrimeric guanine nucleotide-binding (G) proteins are key regulators of cell functions, and they can be found within mitochondria. Therefore, we reasoned that the activation of stimulatory mitochondrial G proteins (G

Indexed as

Cognition DisordersDesigner DrugsMitochondriaAlzheimer DiseaseAnimalsCannabinoidsDisease Models, AnimalFrontotemporal DementiaHumansMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, TransgenicOxygen ConsumptionCannabinoidsDesigner Drugs

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.