Evidence map›Paper›PMID 40790346›Full record

ArticleCommunications biology2025

Single-cell sequencing uncovers disrupted stromal-macrophage communication as a driver of intrauterine adhesion progression.

E Dong, Zhengli Zhou, Tingwei Chen, Bo Zhang, Yu Yin, Xiaomei Wu, Xiaozhuo Li, Jingxue Zhao, Yan He, Jie Yang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Multi-Omics Data Reveal Estrogen-Driven Dysregulation and Stromal-Epithelial Signaling Alterations in Endometrial Polyps.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

E Dong *State Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China. donge@lpbr.cn.ORCID http://orcid.org/0000-0002-0654-0660
Zhengli Zhou *The First people' Hospital of Yunnan Province; the Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Tingwei Chen *State Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Bo ZhangState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yu YinState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID http://orcid.org/0000-0001-6040-6115
Xiaomei WuThe First people' Hospital of Yunnan Province; the Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Xiaozhuo LiState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Jingxue ZhaoThe First people' Hospital of Yunnan Province; the Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
Yan HeState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Jie YangState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Ting LiuState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Naixue YangState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Ran ZhuState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID http://orcid.org/0000-0003-0874-9369
Lujuan RongThe First People's Hospital of Yunnan Province, department of Reproductive Medicine, Kunming, China.
Jiwen TianState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Wenshu ZhouState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Tianqing LiState Key Laboratory of Primate Biomedical Research; Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China. litq@lpbr.cn.ORCID http://orcid.org/0000-0001-7453-0184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine adhesions (IUA), characterized by endometrial fibrosis, pose a serious threat to women's reproductive health, yet their molecular mechanisms remain poorly understood. Here, we use single-cell RNA sequencing (scRNA-seq) to profile 139,395 single cells from nine individuals in the proliferative phase. We identify seven stromal and five macrophage subsets, revealing increased immune cell infiltration and a profibrotic shift in macrophage states. Immunohistochemistry confirms elevated CD68

Indexed as

Cell CommunicationMacrophagesSingle-Cell AnalysisStromal CellsAdultDisease ProgressionEndometriumFemaleFibrosisHumansTissue Adhesions

Identifiers

PMID40790346
PMCPMC12340122

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.