Evidence map›Paper›PMID 40790382›Full record

ArticleMolecular plant pathology2025

6-Hydroxynicotinic Acid From Cucumis melo Inhibits Prehaustorium Formation in Phelipanche aegyptiaca via Disruption of Auxin Signalling Pathway.

Xin Hu, Xiaolei Cao, Lu Zhang, Qiuyue Zhao, Xiaojian Zeng, Yingming Wei, Yinghui Han, Pengyuan Lin, Yunfei Li, Zhaoqun Yao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xin HuKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Xiaolei CaoKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Lu ZhangKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Qiuyue ZhaoKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Xiaojian ZengKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Yingming WeiKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Yinghui HanKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Pengyuan LinKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Yunfei LiKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Zhaoqun YaoKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.
Sifeng ZhaoKey Laboratory of Oasis Agricultural Pest Management and Plant Protection Resources Utilization, Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi, Xinjiang, China.ORCID 0000-0003-1134-9358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phelipanche aegyptiaca, a root holoparasitic weed, severely threatens agricultural productivity due to its detrimental effects. This species relies on a specialised organ, namely the haustorium, to extract nutrients from its host plants. The germination and haustorium formation of P. aegyptiaca are initiated by sensing host plant root exudates. Differences in exudate composition are crucial markers of host resistance. Host plant root exudates significantly influence the development and survival of P. aegyptiaca. To identify root exudates affecting the parasitic weed's growth, we analysed differential metabolites in resistant and susceptible Cucumis melo varieties. Among these, 6-hydroxynicotinic acid was identified as a key compound. Prehaustorium formation, which is induced by haustorium-inducing factors, such as indole-3-acetic acid (IAA), was suppressed in the presence of 6-hydroxynicotinic acid. This compound exerts an inhibitory effect by reducing the expression of genes related to the auxin signalling pathway of P. aegyptiaca, thus weakening parasitism. Our results support a model in which 6-hydroxynicotinic acid inhibits prehaustorium development in P. aegyptiaca by disrupting gene expression and endogenous metabolism.

Indexed as

Cucumis meloIndoleacetic AcidsOrobanchaceaeSignal TransductionGene Expression Regulation, PlantGerminationPlant RootsIndoleacetic Acids6‐hydroxynicotinic acidCucumis meloinhibitionPhelipanche aegyptiacaprehaustoriumroot exudates

Identifiers

PMID40790382
PMCPMC12339233

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.