Evidence map›Paper›PMID 40790397›Full record

ArticlePhysiological reports2025

Adipocyte-specific Krüppel-like factor 14 overexpression confers sex-biased protection from weight gain on a high-fat diet.

Yonathan Tamrat Aberra, Qianyi Yang, Ashlyn Cowan, Bilge Yaylak Gediksiz, Mitchell Thomas, David Gragirenes-Delgado, Foday Keita, Mete Civelek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yonathan Tamrat AberraDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-6055-2291
Qianyi YangDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Ashlyn CowanDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Bilge Yaylak GediksizDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Mitchell ThomasDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
David Gragirenes-DelgadoDepartment of Biology, University of Puerto Rico-Cayey, Cayey, Puerto Rico, USA.
Foday KeitaDepartment of Biology, Howard University, Washington, District of Columbia, USA.
Mete CivelekDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-8141-0284

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
The role of adipocyte KLF14 in Metabolic SyndromeR01DK118287 · NIDDK · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE · 2018 to 2022
$2.4M
Short-Term Training to Increase Diversity in Health-Related ResearchR25HL088724 · NHLBI · UNIVERSITY OF VIRGINIA · PI HALME, ADRIAN J, OWENS, GARY K · 2007 to 2022
$1.8M
American Diabetes Association (ADA) 1-19-IBS-105HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 2T32HL007284HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R25HL088724National Science Foundation (NSF) 2447802NHLBI NIH HHS R25 HL088724NHLBI NIH HHS T32 HL007284NIDDK NIH HHS R01 DK118287
6 · The paper itself

Abstract

Metabolic syndrome, a constellation of cardiometabolic risk factors including abdominal obesity, predisposes individuals to type 2 diabetes and cardiovascular disease. One frequently replicated MetSyn genetic association signal is located near KLF14 and is linked to central adiposity, with stronger effects observed in females. Lower KLF14 expression has been associated with detrimental metabolic phenotypes; however, the therapeutic effect of KLF14 germline overexpression remains unexplored. Here, we generated an adipocyte-specific Klf14 overexpression mouse model to investigate its role in metabolic regulation. Transgenic overexpression conferred sex-dependent metabolic benefits, including reduced weight gain, improved body composition, and enhanced acute insulin sensitivity, predominantly in female mice. These effects were accompanied by increased expression of genes involved in lipid uptake and thermogenic browning of white adipose tissue. Our findings demonstrate that KLF14 overexpression confers protective metabolic effects in a sex-specific manner and support the potential of KLF14-targeted strategies for treating metabolic syndrome.

Indexed as

AdipocytesDiet, High-FatKruppel-Like Transcription FactorsWeight GainAnimalsFemaleInsulin ResistanceMaleMetabolic SyndromeMiceMice, Inbred C57BLMice, TransgenicKlf14 protein, mouseKruppel-Like Transcription Factorsadipose tissueinsulin resistancemetabolic syndromeobesitysex differences

Identifiers

PMID40790397
PMCPMC12339416

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.