ArticleBMC ophthalmology2025
Quantitative comparison of mean macular thickness in COVID-19 patients versus healthy individuals using optical coherence tomography.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association of foveal avascular zone (FAZ) enlargement with SARS-CoV-2 infection and long COVID-19.BMC ophthalmology · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSARS-CoV-2 is associated with systemic inflammation, vascular dysfunction, and potential ocular involvement. While structural retinal changes have been observed in some patients, the long-term impact of COVID-19 on macular architecture remains unclear, §particularly in unvaccinated populations.
objectiveTo evaluate differences in central macular thickness (CMT) between post-COVID-19 patients and healthy individuals using optical coherence tomography (OCT), with age-stratified analysis.
designA prospective case-control study conducted at a specialized ophthalmology center in Brazil during the early vaccination phase. A total of 76 unvaccinated participants were included: 29 patients with prior COVID-19 (58 eyes) and 47 healthy controls (94 eyes). OCT was performed at least 14 days after PCR-confirmed infection.
resultsThe overall mean CMT was 246.93 ± 23.30 μm. No significant difference was found between the COVID-19 and control groups (242.54 ± 19.76 μm vs. 249.63 ± 25.06 μm; p = 0.10). However, among participants aged ≥ 42 years, post-COVID-19 patients had significantly lower CMT compared to age-matched controls (241.00 ± 21.90 μm vs. 256.85 ± 28.58 μm; p = 0.04). No significant difference was observed in the < 42 years group. OCT angiography revealed no qualitative vascular abnormalities in either group.
conclusionOur findings suggest that SARS-CoV-2 infection may be associated with subtle retinal thinning in older adults, even in the absence of acute symptoms or visual complaints. These results highlight the importance of age-stratified analysis and support further investigation into the long-term ocular effects of COVID-19.
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