Evidence map›Paper›PMID 40790598›Full record

ArticleCell & bioscience2025

Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons.

Nicola Brandt, Arne Battefeld, Olga Suckau, Konstantin Stadler, Bhumika Singh, Pei Zhang, Junken Aoki, Jerold Chun, Christian Henneberger, Rosemarie Grantyn and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicola Brandt *Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129, Oldenburg, Germany.
Arne Battefeld *Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Olga Suckau *Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Konstantin StadlerInstitute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Bhumika SinghInstitute of Physiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Pei ZhangInstitute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Junken AokiGraduate School of Pharmaceutical Science, University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan.
Jerold ChunThe Scripps Research Institute, 10550 North Torrey Pines Read, La Jolla, San Diego, CA, 92037, USA.
Christian HennebergerInstitute of Physiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Rosemarie GrantynInstitute of Physiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Johannes VogtDepartment of Molecular and Translational Neuroscience, Institute of Anatomy II, University of Cologne, Faculty of Medicine and University Hospital Cologne, 50931, Cologne, Germany.
Robert NitschInstitute for Translational Neuroscience, Medical Faculty, Westfälische Wilhelms-University Münster, 48149, Münster, Germany.
Ulf Strauss *Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Anja U Bräuer *Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129, Oldenburg, Germany. anja.braeuer@uni-oldenburg.de.ORCID http://orcid.org/0000-0003-3651-1470

Funding

Deutsche Forschungsgemeinschaft BR 2345/1-1
6 · The paper itself

Abstract

backgroundLysophosphatidic acid (LPA) is a bioactive phospholipid that affects hippocampal excitatory synaptic transmission.

resultsHere we provide in vitro evidence that LPA elicits intracellular calcium concentration ([Ca

conclusionsTaken together, our data further support membrane derived phospholipids as active modulators of excitatory synaptic transmission.

Indexed as

Calcium imagingHippocampusLPALPA2 receptormEPCSNeuron

Identifiers

PMID40790598
PMCPMC12341218

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.