Evidence map›Paper›PMID 40790750›Full record

ArticleJournal of translational medicine2025

Polystyrene microspheres could inhibit the ferroptosis of prostate cancer cells via USP39/IGF2BP3/MAPK4 axis.

Shengming Lu, Ruipeng Wu, Weijian Li, Zhenyu Fu, Xuefei Ding, Yang Luan, Huang Tianbao, Yuhua Huang

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In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shengming Lu *Department of Urology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.
Ruipeng Wu *Department of Urology, Second People's Hospital of Bengbu City, Bengbu, Anhui, China.
Weijian LiFudan Institute of Urology, Fudan University, Shanghai, China.
Zhenyu FuDepartment of Urology, Changshu Second People's Hospital, Changshu, Jiangsu, China.
Xuefei DingDepartment of Urology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Yang LuanDepartment of Urology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Huang TianbaoDepartment of Urology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Yuhua HuangDepartment of Urology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China. sdfyy_hyh@163.com.ORCID 0000-0002-0341-0078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolystyrene (PS) particles, which have been recognized as emerging environmental pollutants, have increasingly been associated with various human diseases. However, their specific role and underlying mechanisms in prostate cancer development have not been fully elucidated.

methodsWe investigated the characterization properties of PS particles. Subsequently, we examined the impact of PS particles on prostate cancer proliferation using in vitro experiments. Through mRNA sequencing, RIP, and mass spectrometry analysis, we confirmed a close interaction among USP39, IGF2BP3, and MAPK4. The rescue experiment demonstrated that ferroptosis is intricately involved in this process. To further validate our results, we performed mouse xenograft experiments.

resultsIn this study, PS particles significantly enhanced the proliferation, migration, and invasion of prostate cancer cells through the regulation of ferroptosis. It was found that USP39 interacts with IGF2BP3, which, in turn, stabilizes MAPK4, a key regulator of ferroptosis.

conclusionsThese findings illuminate the complex relationship between environmental pollutants such as PS and cancer progression, offering new avenues for research and potential therapeutic interventions in prostate cancer.

Indexed as

FerroptosisMicrospheresPolystyrenesProstatic NeoplasmsRNA-Binding ProteinsAnimalsCell Line, TumorCell MovementCell ProliferationHumansMaleMiceNeoplasm InvasivenessSignal TransductionXenograft Model Antitumor AssaysPolystyrenesRNA-Binding ProteinsFerroptosisProstate cancerUbiquitination

Identifiers

PMID40790750
PMCPMC12341314

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.