Evidence map›Paper›PMID 40790909›Full record

Trial reportJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2025

Treating cellulitis promptly with compression therapy reduces C-reactive protein-levels and symptoms - a randomized-controlled trial.

Sören Dräger, Charlotte Kiehne, Greta Zinser, Birgit Kahle

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Treating cellulitis promptly with compression therapy reduces C-reactive protein-levels and symptoms - a randomized-controlled trial.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sören DrägerDepartment of Dermatology, Allergology and Venereology, University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.ORCID 0000-0002-3701-8365
Charlotte KiehneDepartment of Dermatology, Allergology and Venereology, University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.
Greta ZinserDepartment of Dermatology, Allergology and Venereology, University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.
Birgit KahleDepartment of Dermatology, Allergology and Venereology, University Medical Center Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesCellulitis is an acute bacterial infection of the skin. Initial treatment primarily consists of systemic antibiotic therapy. Compression therapy is subsequently introduced to reduce edema. However, the optimal timing for initiating compression therapy remains a subject of debate, as early application is thought to potentially exacerbate the infection. PATIENTS AND

methodsThis study was designed as a prospective, randomized controlled trial. Patients admitted for treatment of lower leg cellulitis were recruited and randomly assigned in a 1:1 ratio. In addition to standard therapy, the intervention group received compression therapy one day after initiation of antibiotic treatment, using medical adaptive compression wraps. C-reactive protein (CRP) levels, reduction in erythema, and patient-reported symptoms were recorded.

resultsA total of 34 patients were included in the analysis. Early application of medical adaptive compression wraps alleviated symptoms without causing complications. In patients with initial CRP levels above 50 mg/dl at admission, CRP reduction occurred more rapidly.

conclusionsOur data suggest that the early application of medical adaptive compression wraps within 24 hours of initiating antibiotic treatment alleviates symptoms, supports recovery, and does not lead to worsening of inflammation.

Indexed as

CellulitisCompression BandagesC-Reactive ProteinAdultAgedAnti-Bacterial AgentsCombined Modality TherapyFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeAnti-Bacterial AgentsC-Reactive Proteincellulitiscompression therapymedical adaptive compression wraps

Identifiers

PMID40790909
PMCPMC12548327

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.