Evidence map›Paper›PMID 40791539›Full record

ArticlebioRxiv : the preprint server for biology2025

Distinct Synaptic Mechanisms Drive

Jay English, Danny McSweeney, Jinghui Geng, Ethan Howell, Fumiko Ribbe, Matthew Hinderhofer, Lydia Proskauer, Rebecca Sebastian, Le Wang, Tal Sharf and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jay EnglishDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Danny McSweeneyDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Jinghui GengDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064.
Ethan HowellDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Fumiko RibbeDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Matthew HinderhoferDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Lydia ProskauerDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Rebecca SebastianDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.
Le WangDepartment of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95064.
Tal SharfDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95064.
Zhiping P PangDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, New Brunswick, NJ 08901.ORCID 0000-0002-6183-1233
ChangHui PakDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst MA 01003.ORCID 0000-0003-4192-7665

Funding

Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Molecular dissection of synaptic dysfunction in mental disordersR01MH122519 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PAK, CHANGHUI · 2020 to 2024
$2.3M
NIGMS NIH HHS T32 GM135096NIMH NIH HHS R01 MH122519
6 · The paper itself

Abstract

Copy number deletions in the 2p16.3/

Indexed as

Autism spectrum disordersE-I balanceHD-MEAshuman iPSCsinduced neuronsNRXN1schizophreniasynapsesynaptic transmission

Identifiers

PMID40791539
PMCPMC12338733

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.