In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
34 authors.
Vera FominykhCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-5490-2390 Piotr JaholkowskiCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Alexey A ShadrinCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-7467-250X Elise KochCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-3727-4470 Dorte H MikkelsenInstitute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-7360-4812 Mischa LundbergInstitute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-4816-785X Sisse Rye OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-5288-3851 Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark & Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-6551-6647 Maria DidriksenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-4856-496X Christina MikkelsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-2945-6197 Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Kaarina KowalecCollege of Pharmacy and Department of Biochemistry & Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Canada.ORCID 0000-0003-3928-9879 Håkan KarlssonDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Pravesh ParekhCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-1930-1167 Viktoria BirkenæsCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-3194-1535 Ida E SønderbyCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-7297-7855 DBDS genetic consortium
Estonian Biobank research team
Olav B SmelandCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-3761-5215 Kevin S O'ConnellCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-6865-8795 Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Thomas M WergeInstitute of Biological Psychiatry, Mental Health Services Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0003-1829-0766 Ole A AndreassenCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568 Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MNIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA055330NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196NIMH NIH HHS R01 MH124839
6 · The paper itselfAbstract
Somatic symptom and related disorders (SSRD) are characterized by a mixture of neurological and psychiatric features and include functional neurological (FND) and somatic symptom disorders (SomD). While these complex neuropsychiatric disorders show evidence of genetic susceptibility, there are no genome-wide association studies (GWAS) of SSRD, and the heritability is unknown. We did a GWAS of a total of 22,203 patients with SSRD, and 1,831,107 controls of European ancestry. We identified one genome-wide significant locus (chromosome 8:65565084) in SSRD, and one additional locus (chromosome 16:49074278) in the SomD subgroup (n cases = 18,536). The observed-scale SNP heritability was estimated to be 7.3 % for SSRD, 15.7 % for FND and 7.7 % for SomD. FND and SomD were strongly genetically correlated (rg=0.94, SE=0.11, p=3.9E-18). SSRD showed significant genetic correlation with psychiatric disorders (highest with anxiety, post-traumatic stress disorders, depression, rg=0.3-0.8), neurological disorders (migraine, chronic pain, rg=0.4-0.6) and immune-related diseases (rg=0.2-0.3). Functional follow-up analysis of SSRD loci implicated the genes
Indexed as
AllOfUsEstonian BiobankFinnGenfunctional movement disordersfunctional neurological disordersgeneticsgenome-wide association studiesGWASMoBasomatoform disordersUKB
Identifiers
PMID40791713
PMCPMC12338935
What Socratic holds
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