ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Divergent effects of age on imaging-based ATN biomarkers and cognition in Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Divergent effects of age on imaging-based ATN biomarkers and cognition in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer Disease.Alzheimer disease and associated disordersArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe investigated whether age of patients with Alzheimer's disease (AD) at first visit to a memory clinic predicts biomarker findings along the amyloid beta deposition, pathologic tau, and neurodegeneration (ATN) scheme and moderates the association between ATN biomarkers and cognition.
methodsWe evaluated [
resultsTau burden and hypometabolism were more severe in younger AD patients. Gray matter volume of the medial temporal lobe (MTL) was reduced to a greater extent in older patients. Relationships between different imaging modalities or between single imaging modalities and cognition were not moderated by age. DISCUSSION: In contrast to more severe tau burden and hypometabolism in younger patients, MTL atrophy was more pronounced in older patients. Relationships between markers of pathology and those of neurodegeneration were not associated with age. Highlights: Amyloid beta load as a biomarker of pathology burden was not associated with age at first visit to a memory clinic.Tau burden was higher, and glucose metabolism was lower in younger Alzheimer's disease (AD) patients.By contrast, medial temporal lobe atrophy was less severe in younger AD patients.Younger AD patients showed more severe memory deficits with respect to age-appropriate normative data.Age had no moderating effect on relationships between different imaging variables or between single imaging variables and cognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.