ArticleBrain, behavior, & immunity - health2025
Associations between the gut microbiota at one-year and neurodevelopment in children from the SEPAGES cohort.
Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Effects of vaginal microbiota transfer on social-emotional and neurodevelopment in cesarean-born infants: 12-month follow-up of a pilot randomized clinical trial.Acta obstetricia et gynecologica Scandinavica · 2026Trial
- From microbes to milestones: Gut bacterial abundances and functional pathways associate with neurodevelopment following preterm birth.Gut microbiology · 2026Article
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- Research on the role of gut microbiota metabolites in autism by multi-omics and network pharmacology.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fundamental research indicates a communication between the gut microbiota and the central nervous system, referred to as the microbiota-gut-brain axis. This link is little characterized in humans in the general population. We prospectively investigated the relationships between the gut microbiota composition of one-year-old children and neurodevelopment parameters at 2 and 3 years of age. Within the SEPAGES French couple-child cohort, we profiled gut microbiota by sequencing the V3-V4 region of the 16S rRNA gene from stool samples in 356 children at 12 months of age. We later assessed children's neurodevelopment through validated tests (CBCL at 2 years, and SRS-2, BRIEF-P and WPPSI-IV at 3 years). Microbial α-diversity indices, the 4 most abundant phyla, and the 46 most abundant genera were analyzed for their relations with neurodevelopmental parameters using multiple linear regression, while associations of β-diversity with neurodevelopment were examined through PERMANOVA tests. α- and β-diversity indices were not associated with neurodevelopmental parameters in children. Suggestive associations were observed with taxonomy, but not maintained after correction for multiple comparisons: phyla Proteobacteria and Bacteroidetes tended to be associated with higher socio-emotional neurodevelopment assessed with different sub-scores; phylum Firmicutes with increased plan and organization problems; genera
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.