Evidence map›Paper›PMID 40792064›Full record

ArticleAging brain2025

Sex differences in the association between episodic memory residual reserve index and change in executive function.

Cheyenne Chooi, Brandon E Gavett, David Ames, Paul Maruff, Vincent Doré, Victor L Villemagne, Pierrick Bourgeat, Ying Xia, Colin L Masters, Ralph N Martins and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cheyenne ChooiSchool of Psychological Science, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia.
Brandon E GavettSchool of Psychological Science, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia.
David AmesNational Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia.
Paul MaruffUniversity of Melbourne Academic Unit for Psychiatry of Old Age, St George's Hospital, Kew, Victoria, Australia.
Vincent DoréCogstate Ltd, Melbourne, Victoria, Australia.
Victor L VillemagneDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Pierrick BourgeatThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Ying XiaThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Colin L MastersThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Ralph N MartinsDepartment of Biomedical Sciences, Macquarie University, New South Wales, Australia.
Kevin TaddeiSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
Michael WeinbornSchool of Psychological Science, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia.
Stephanie R Rainey-SmithSchool of Psychological Science, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia.

Funding

Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
NIA NIH HHS R01 AG031563
6 · The paper itself

Abstract

Sex differences in cognitive reserve might contribute to females being disproportionately affected by Alzheimer's disease (AD). We investigated sex differences in the protective effects of cognitive reserve, and whether brain beta-amyloid accounts for differences. Older adults (n = 997 from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing) diagnosed as Cognitively Normal, Mild Cognitive Impairment, or AD at baseline were assessed every 18 months for up to a maximum of seven visits. Cognitive reserve was calculated from the variance in episodic memory not explained by demographic or brain measures. Executive functioning (EF) intercept and slope were regressed onto the main and interaction effects of cognitive reserve x brain integrity x sex, plus covariates (age, number of

Indexed as

Alzheimer’s diseaseBeta-amyloidCognitive reserveEpisodic memoryResidual reserve indexSex differences

Identifiers

PMID40792064
PMCPMC12336049

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.