ArticleInternational journal of general medicine2025
Study of the Association of
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Association ofPakistan journal of medical sciences · 2026Article
- Activation of the Endothelin System in Chronic Kidney Disease and Kidney Transplant Recipients-Implications for Disease Progression.International journal of molecular sciences · 2026Article
- In silico prioritisation of EDN1 missense variants identifies mature endothelin-1 substitutions with predicted receptor-binding effects.BMC genomics · 2026Article
- Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Type 2 diabetes mellitus (T2DM) is common in the Arab population. Endothelin-1 (ET-1) is an a vasoconstrictor agent produced by the endothelin-1 gene ( Methods: The investigation was a case-control study and included 190 T2DM patients and 120 healthy subjects. Polymerase chain reaction was employed to determine rs5370 genotypes among the study participants. Results: The frequency of the G allele was 78.3% among the control group and 74.7% in T2DM (P=0.306). Plasma ET-1 protein levels were higher in T2DM than in controls (p<0.01). However, no association was found between rs5370 and T2DM. The frequencies of GG, GT, and TT genotypes were 60.8%, 35%, and 4.2% in the control group and 53.7%, 42.1%, and 4.2% in the patient group, respectively (P=0.447). With respect to T2DM complications, a significantly higher incidence of nephropathy was observed among patients with TT/GT genotypes compared to patients with the GG genotype (P<0.05). Furthermore, a marginal statistical significance was found between rs5370 and cardiovascular diseases in T2DM (P=0.06). Conclusion: Circulatory ET-1 levels were elevated in T2DM. The EDN1 rs5370 polymorphism might impact the development of nephropathy in T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.