ReviewBioactive materials2025
Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives.
Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Three-dimensional printed PCL/nHA scaffolds promote soft tissue functional fibrosis to repair chest wall defect via Piezo1/CaBioactive materials · 2026Article
- Clinical and Radiographic Outcomes of Two-Stage Allograft-Augmented Fixation Versus Conventional Posterior Segmental Stabilization for Screw Loosening.Journal of clinical medicine · 2026Article
- From Concept to Clinic: Pre-Clinical Testing and Regulatory Considerations in Spine Implant Development.JOR spine · 2026Review
- Comparative Wear Evaluation of Pure Zn, Zn-Mg and Zn-Mg-Y Alloys Using Mass Loss Measurements and Optical Profilometry.Materials (Basel, Switzerland) · 2026Article
- Three-Dimensional Printing of a Spinal Interbody: Design Principles, Biomaterials, and Translational Considerations.Journal of functional biomaterials · 2026Review
- Biofunctional Testing of a Degradable Implant Made by Mg-Nd and Mg-Zn Alloys Used for Bone Defects.Biomimetics (Basel, Switzerland) · 2026Article
- Review
- A Review of Synthetic Bone Grafts in Lumbar Interbody Fusion.Bioengineering (Basel, Switzerland) · 2026Review
- Long-term Performance and Durability of Biomaterials and Implant Designs in Total Joint Arthroplasty and Spinal Fusion.Journal of orthopaedics and sports medicine · 2026Article
- Is Anterior Longitudinal Ligament Rupture During Posterior Corrective Surgery for Adult Spinal Deformity a Phenomenon Unique to When Combined with Lateral Lumbar Interbody Fusion? -Finite Element Analysis with Comparison to When Combined with Posterior Lumbar Interbody Fusion-Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal fusion is considered today as the last treatment option for different spinal conditions, such as degenerative and infectious illnesses. It consists of fusing two or more vertebrae to obtain reinforcement/fixation based on several methods used to sustain osteosynthesis and grafting, such as cage insertion in the intervertebral space, which provides an important level of mechanical stability, impacting only a low amount of the natural biomechanics of the spine and facilitating the implant bony ingrowth. This review paper first explores the background of intervertebral fusion, emphasizing medical applications and material properties of interbody fusion cages. It then provides a brief historical overview and discusses antibacterial efficacy-related issues. Additionally, some of the most met-in-clinical practice lumbar interbody cages with a detailed description of their geometry and examples of clinical trials performed worldwide are provided. The biomaterials used in lumbar cage manufacture are comprehensively described. In the last part of this review paper, special attention is devoted to prospective biomaterials and coatings for spine fusion cages. Firstly, the rationale for using Mg-based alloys or high osteogenic polycaprolactone as biodegradable and bioresorbable alternatives in the spinal cage industry, addressing the clinical limitations of traditional Ti alloys and polyether ether ketone, is provided. Then, a more conservative approach, focusing on the use of bioactive or antibacterial coatings on the already certified biomaterials, is presented as a second alternative to the existing products on the market. Relevant literature studies are reviewed, and the osteointegrative, bioactive, or antibacterial character of the coatings is explained. Finally, our review identifies current clinical limitations and offers future perspectives that will provide better bioactive solutions, improving the existing biomaterials.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.