ReviewAlcohol research : current reviews2025
Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.
Review in Alcohol research : current reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeMore than half of people with HIV (PWH) in the United States are now over age 50. Although alcohol consumption declines with age among PWH, as it does in the general population, alcohol misuse and alcohol use disorder (AUD) pose substantial health risks. Aging leads to increased sensitivity to alcohol due to slower metabolism, central nervous system changes, less lean body mass, greater prevalence of co-occurring medical conditions, and polypharmacy (simultaneous use of multiple medicines). These vulnerabilities heighten the adverse effects of alcohol use among older PWH compared with both younger PWH and people without HIV of all ages. This review examines associations between alcohol use and three interrelated health outcomes of growing research interest-frailty, fractures, and falls-each of which has substantial negative impacts on longevity and quality of life among PWH and may be influenced by alcohol use. SEARCH
methodsSearch terms included alcohol, drinking, binge drinking, heavy drinking, AUD, alcohol abuse, alcohol dependence, problematic alcohol use, mild/moderate alcohol use, high-intensity drinking, risky drinking, alcoholism, frailty, falls, fractures, HIV, PWH, PLWH, ART, and AIDS. All studies included PWH age 50 and over. In June 2024, authors identified original studies published in English between June 1, 2014, and June 1, 2024, by searching PubMed, Web of Science, and ScienceDirect and reviewing reference lists of reviews and meta-analyses identified in the search. SEARCH
resultsSearches yielded a total of 512 articles; 114 duplicates were removed. Two independent reviewers screened the abstracts of the remaining 398 articles, of which 326 articles were excluded based on having inappropriate sampling, exposures, or outcome measures. Seventy-two articles underwent full-text review; of these, 14 articles met inclusion criteria and 58 articles were excluded. Reasons for exclusion were wrong outcomes ( DISCUSSION AND
conclusionsResults across the 14 studies indicated that, among older PWH, greater alcohol use was linked to higher risk of frailty, fractures, and falls. However, evidence was limited, with most literature based on observational studies. Important future potential research directions include longitudinal assessments of alcohol-frailty relationships among PWH age 50 and over; evaluating the role of alcohol use in the development and progression of frailty accounting for mid- and later-life comorbidity and resultant polypharmacy; and examining moderators of the alcohol-frailty relationship. Future research examining interventions to reduce risk of frailty, fractures, and falls among aging PWH also would be beneficial.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.