Evidence map›Paper›PMID 40793754›Full record

ArticleMicrobiology spectrum2025

TlyC, a conserved hemolysin in

Luke Helminiak, Smruti Mishra, Ivy Lu, Hwan Keun Kim

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luke HelminiakCenter for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA.
Smruti MishraCenter for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA.
Ivy LuCenter for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA.
Hwan Keun KimCenter for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0003-2095-9705

Funding

MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
Molecular basis of immunity to tick-borne rickettsiosesR01AI152208 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KIM, HWAN KEUN · 2021 to 2025
$2.8M
Transposon mutagenesis of Rickettsia for studying Rickettsia-host-vector interactionsR61AI179732 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Hwan Keun Kim · 2024 to 2026
$837k
Host-pathogen-vector interactions of R. amblyommatis for spotted fever pathogenesisR21AI169287 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KIM, HWAN KEUN · 2022 to 2023
$425k
NIAID NIH HHS R01 AI152208NIAID NIH HHS R21 AI169287NIAID NIH HHS R61 AI179732NIAID NIH HHS T32 AI007539NIH HHS R01AI152208, R21AI169287, R61AI179732Stony Brook University
6 · The paper itself

Abstract

IMPORTANCE: Rickettsiosis is a vector-borne disease that causes systemic and potentially fatal vasculitis if not diagnosed promptly and treated with antibiotics. Pathogenic

Indexed as

Bacterial ProteinsHemolysin ProteinsRickettsiaRickettsia conoriiSpotted Fever Group RickettsiosisAnimalsDisease Models, AnimalErythrocytesHemolysisHumansMiceVirulenceVirulence FactorsBacterial ProteinsHemolysin ProteinsVirulence FactorshemolysispathogenesisRickettsiasecretionTlyC

Identifiers

PMID40793754
PMCPMC12403716

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.