ArticleJournal of cellular and molecular medicine2025
The Transcription Factor CREB1 Triggers the Progression of Clear Cell Renal Cell Carcinoma by Promoting CENPE Expression.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Network Pharmacology-Based Identification of Potential Targets and Mechanisms of Isoginkgetin in Gastric Cancer.BioMed research international · 2026Article
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Authors and funding
8 authors.
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Abstract
Centromere-associated protein E (CENPE) has been identified as overexpressed in multiple cancers and exerts a tumour promotion function by affecting chromosome misalignment and mitosis. However, the expression pattern, biological roles, and underlying molecular mechanism of CENPE in clear cell renal cell carcinoma (ccRCC) progression have not been fully elucidated. In the present study, the expression levels of CENPE in ccRCC and paracancerous specimens were measured using the public RNA sequencing data and validated in a cohort of ccRCC samples from our centre. We found that CENPE was significantly over-expressed in ccRCC tissues and promoted proliferative and metastatic abilities of ccRCC cells and xenografts through regulating the epithelial-mesenchymal transition (EMT) process. Furthermore, bioinformatic analysis and ChIP assay indicated that the transcription factor CREB1 bound to the promoter region of CENPE and activated its transcription in ccRCC cells. Taken together, our findings demonstrated that the CREB1-CENPE axis was responsible for stimulating the in vitro and in vivo progression of ccRCC, serving as a promising therapeutic target for ccRCC.
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