ReviewCurrent osteoporosis reports2025
Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity.
Review in Current osteoporosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Piezo1, Integrins, and YAP/TAZ in Osteoporotic Mechanotransduction: Key Pathways, Crosstalk, and Therapeutic Implications.Calcified tissue international · 2026Review
- Bone tissue regeneration: role of osteocyte mechanosensing and mechanotransduction.Stem cells translational medicine · 2026Review
- Mechano-immune interactions in musculoskeletal aging: Mechanisms and translational perspectives.Theranostics · 2026Review
- Circadian regulation of osteoclast lysosomal-resorption machinery: implications for osteoporosis therapy.Frontiers in cell and developmental biology · 2026Review
- Bidirectional crosstalk between the bone extracellular matrix and lysosomes in bone remodeling and osteoporosis.Frontiers in endocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewBone matrix is a multiscale composite material mainly composed of collagen, crystalline apatite mineral, water, and a small amount of non-collagenous proteins. Nested within bone matrix, mechanosensitive osteocytes orchestrate bone adaptation to mechanical loading, which is affected by the ultrastructural composition and mechanical properties of the osteocyte-surrounding bone matrix. In this review, we shed light on the impact of ageing-related modifications in ultrastructural composition of bone matrix on the mechanosensitivity of osteocytes. RECENT
findingsAgeing modulates the ultrastructural composition of bone matrix, such as collagen cross-links, mineral crystal size, microcracks, content of bound water, content and phosphorylation of non-collagenous proteins, and degree of mineralization. These ageing-related modifications alter the mechanical properties of bone matrix, and the biological function of bone, i.e. altered mechanical properties lead to changes in mechanical loading-induced fluid shear stress experienced by osteocytes, which affect osteocyte mechanosensitivity. A better understanding of the role of osteocyte mechanosensitivity in bone adaptation to mechanical loading during ageing is crucial. This review highlights the ageing-related changes in the ultrastructural composition and mechanical properties of bone matrix, that might affect the mechanosensitivity of osteocytes. By linking ageing-related changes in the bone matrix to alterations in osteocyte mechanosensitivity, it is assumed that ageing-modulated bone matrix affects bone adaptation to mechanical loading orchestrated by osteocytes. A comprehensive understanding of how age-related changes in bone matrix composition influence osteocyte mechanosensitivity is crucial for explaining the fragility of ageing bone, as osteocytes are the most abundant and mechanosensitive cells in bone tissue.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.