ArticleJournal of molecular neuroscience : MN2025
LncRNA-miRNA‒mRNA Network in Schizophrenia.
Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Transcription Factors in the Pathogenesis of Schizophrenia.Life (Basel, Switzerland) · 2026Review
- Peripheral lncRNA-IL1RAP Dysregulation in Schizophrenia: A Multi-Omics Bridge Between Immunity and Diagnosis.Brain and behavior · 2026Article
- LncRNA CARD8-AS1 acts as a potential novel biomarker and promotes atrial fibrillation progression via the miR-31-5p/ARRB1 pathway.Molecular genetics and genomics : MGG · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SCZ) is a severe mental disorder that significantly impacts the social functioning of patients and can reduce their life expectancy and quality of life. However, the specific causes of SCZ remain unknown, and the evidence indicates that long noncoding RNAs (lncRNAs) play critical roles in its pathogenesis. Analyzing lncRNA expression in peripheral blood samples from patients could reveal the biological mechanisms underlying the disease and help in the identification of biomarkers for early diagnosis and treatment. This study utilized whole-transcriptome sequencing to analyze lncRNA expression in 5 SCZ patients and 5 healthy controls. We constructed lncRNA‒microRNA (miRNA) and miRNA‒messenger RNA (mRNA) interaction pairs and established a competing endogenous RNA (ceRNA) network. Additionally, a weighted gene coexpression network analysis (WGCNA) and lncRNA‒RNA binding protein (RBP) network construction were performed. The potential functions of the mRNAs were predicted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. A total of 438 differentially expressed lncRNAs (DElncRNAs) were identified in patients with SCZ compared with controls, with 260 upregulated and 178 downregulated. The ceRNA network comprised 383 DElncRNAs, 304 miRNAs, and 1849 mRNAs. GO and KEGG analyses indicated that these genes are involved in pathways such as the HIF-1 signaling pathway and oxidative phosphorylation, both of which are relevant to SCZ. Based on the ceRNA network-derived mRNAs, WGCNA identified three disease-associated modules. Furthermore, interactions between RBPs and DElncRNAs may play a significant role in the pathophysiology of SCZ. This study identifies 438 dysregulated lncRNAs in SCZ, constructs a ceRNA network implicating HIF-1 signaling and oxidative phosphorylation pathways, and reveals disease-associated coexpression modules and RBP-lncRNA interactions, providing novel insights into SCZ pathogenesis and potential diagnostic biomarkers.
Indexed as
Identifiers
40794250What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.