Evidence map›Paper›PMID 40794340›Full record

Observational studyInternational ophthalmology2025

Impact of the COVID-19 pandemic on the incidence and recurrence of central serous chorioretinopathy in Greece: a multicenter study.

Alexandros Rouvas, Ioannis Datseris, Ilias Georgalas, Miltiadis Tsilimbaris, Paris Tranos, Panagiotis Theodosiadis, Malvina-Efthimia Tzanidaki, Marina Kardara, Konstantinos Tyrlis, Dimitrios Spyropoulos and 5 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexandros Rouvas2nd Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'Attikon' University General Hospital, 1 Rimini Str., Haidari, 12462, Athens, Greece.
Ioannis Datseris'OMMA' Eye Institute, Athens, Greece.
Ilias Georgalas1st Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'G. Gennimatas' General Hospital, Holargos, Athens, Greece.
Miltiadis TsilimbarisDepartment of Opthalmology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Paris TranosOphthalmica" Eye Institute, Thessaloniki, Greece.
Panagiotis Theodosiadis2nd Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'Attikon' University General Hospital, 1 Rimini Str., Haidari, 12462, Athens, Greece.
Malvina-Efthimia Tzanidaki'OMMA' Eye Institute, Athens, Greece.
Marina Kardara'OMMA' Eye Institute, Athens, Greece.
Konstantinos Tyrlis1st Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'G. Gennimatas' General Hospital, Holargos, Athens, Greece.
Dimitrios Spyropoulos1st Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'G. Gennimatas' General Hospital, Holargos, Athens, Greece.
Rafaela DatseriDepartment of Opthalmology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Anastasios StavrakakisDepartment of Opthalmology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Marianna TranouOphthalmica" Eye Institute, Thessaloniki, Greece.
Pavlina KazantzidouOphthalmica" Eye Institute, Thessaloniki, Greece.
Nikolaos Gouliopoulos2nd Department of Ophthalmology, Medical School of National and Kapodistrian University of Athens, 'Attikon' University General Hospital, 1 Rimini Str., Haidari, 12462, Athens, Greece. ngouliopoulos@yahoo.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the impact of the COVID-19 pandemic on the incidence and recurrence of central serous chorioretinopathy (CSCR) in Greece, analyzing data from 2017 to 2023.

methodsA retrospective, observational, cross-sectional study was conducted, including patients diagnosed with either new-onset or recurrent CSCR at five ophthalmology departments in Greece from January 2017 to December 2023. Data were categorized into "pre-COVID" (2017-2019) and "COVID" (2021-2023) periods, excluding cases from 2020 due to lockdown restrictions. Patient demographics, disease recurrence, and COVID-19 infection history were recorded. Statistical analyses included chi-square tests, Spearman's rank correlation, and Student's t-test.

resultsA total of 730 CSCR cases were analyzed (435 new-onset, 295 recurrent). The participants' mean age was 46.8 ± 7.5 years. The overall number of cases significantly increased during the COVID-19 period (462 cases) compared to the pre-COVID period (268 cases) (p < 0.001). Both new-onset (164 vs. 271, p < 0.001) and recurrent cases (104 vs. 191, p < 0.001) showed a significant rise. Among patients from 2021 to 2023, those with a confirmed COVID-19 infection had significantly higher CSCR rates compared to non-infected individuals (p < 0.001).

conclusionThe COVID-19 pandemic was associated with a significant increase in CSCR incidence and recurrence in Greece. This rise may be attributed to heightened psychological stress and endogenous cortisol elevation during the pandemic, as well as direct viral effects and corticosteroid use in infected patients. Further studies are needed to explore underlying mechanisms and long-term consequences.

Indexed as

Central Serous ChorioretinopathyCOVID-19SARS-CoV-2AdultCross-Sectional StudiesFemaleGreeceHumansIncidenceMaleMiddle AgedPandemicsRecurrenceRetrospective StudiesCentral serous chorioretinopathyCOVID-19Mental health

Identifiers

PMID40794340

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.