ArticleDiscover oncology2025
Independent effects of mental health disorders on breast cancer and their mediating factors: evidence from NHANES and two-step Mendelian randomization.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Orbital Metastases of Breast Cancer: Case Report and Review of the Literature.Oncology research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe epidemiological data regarding the correlation between mental disorders and breast cancer (BC) is still debatable. This study's objective is to clarify the connection between BC and mental disorders, such as depression, panic, and anxiety, in addition to examining the mediating role of risk factors associated with BC through genetic susceptibility.
methodsCross-sectional data came from the National Health and Nutrition Examination Survey (NHANES) for the years 2015-2018, stratified by BC status. Summary statistics of genome-wide association studies (GWASs) of mostly European ancestry were used for Mendelian randomization (MR) analysis. The connections between depressive symptoms, anxious symptoms, and anxiety medication use and breast cancer were assessed using logistic regression models. The independent effects of depression, panic, and anxiety on BC were estimated through two-sample multivariable MR. Furthermore, 23 possible mediators of the connection were assessed and mediated proportions were computed using two-step MR.
resultsCross-sectional data revealed that participants taking medication for anxiety were at higher risk of BC (OR (95%CI): 2.18 (1.29-3.70), P < 0.01). Using multivariate MR to adjust for depression, anxiety, and panic, only anxiety was still strongly correlated with the occurrence of overall (β
conclusionOur findings suggests that anxiety susceptibility at the genetic level is a distinct risk factor for BC, with no mediators identified in this process.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.