Evidence map›Paper›PMID 40794423›Full record

ArticleThe Journal of international medical research2025

CircDock6 drives metabolic dysfunction-associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation.

Hongpeng Lu, Xiaoyun Ding, Peifei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hongpeng LuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, China.
Xiaoyun DingDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, China.
Peifei LiDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, China.ORCID 0000-0002-9855-5711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveCircular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction-associated steatotic liver disease. This study sought to examine the functional role and molecular mechanism of circDock6 in metabolic dysfunction-associated steatotic liver disease.MethodsQuantitative reverse transcription polymerase chain reaction was performed to determine

Indexed as

Fatty LiverHepatocytesMicroRNAsNon-alcoholic Fatty Liver DiseaseReceptor, IGF Type 1RNA, CircularAnimalsDiet, High-FatDisease Models, AnimalDisease ProgressionGene Expression RegulationHumansInsulin-Like PeptidesLiverMaleMiceIgf1r protein, mouseInsulin-Like PeptidesMicroRNAsReceptor, IGF Type 1RNA, Circularcircular RNAinsulin-like growth factor 1 receptorlipid metabolismMetabolic dysfunction–associated steatotic liver diseasemmu-let-7g-5p

Identifiers

PMID40794423
PMCPMC12344330

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.