ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025
Down-Regulation of Klotho/FGF23 by Low-Expressed VEGFR2 Inhibits the GH/IGF-1/PI3K/AKT Signaling Pathway Inducing Intrauterine Growth Restriction in Rats.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Down-Regulation of Klotho/FGF23 by Low-Expressed VEGFR2 Inhibits the GH/IGF-1/PI3K/AKT Signaling Pathway Inducing Intrauterine Growth Restriction in Rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
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3 authors.
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Abstract
problemIntrauterine growth restriction (IUGR) is a pregnancy complication characterized by failure of the fetus to reach its genetic growth potential. We established the association Klotho, fibroblast growth factor 23 (FGF23), and vascular endothelial growth factor receptor 2 (VEGFR2) with IUGR for the first time, hoping to provide new insights for its diagnosis and treatment. METHOD OF STUDY: Sixteen pregnant rats were randomly divided into a low-protein diet group (IUGR group) and a control group. Placental tissues were sampled to detect Klotho, FGF23, VEGFR2 mRNA, and protein expression in placental tissues of pregnant rats using quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. Bioinformatics methods were also used to predict the signaling pathways involved in Klotho, FGF23, and VEGFR2.
resultsThe weight and crown-rump length of fetal rats in the IUGR group were significantly lower than those in the control group (p < 0.05). The expression levels of Klotho, FGF23, and VEGFR2 in IUGR group placental tissues were significantly lower than those in the control group (p < 0.05). Meanwhile, based on bioinformatics, it was predicted that VEGFR2 might affect the activation of the PI3K/AKT signaling pathway by growth hormone (GH)/insulin-like growth factor-1(IGF-1) through Klotho/FGF23 axis inhibition.
conclusionsIUGR caused by a low protein diet reduced birth weight and crown-rump length and low expression of Klotho, FGF23, and VEGFR2 in placental tissues, which may inhibit fetal growth through the VEGFR2-Klotho-FGF23-GH-IGF-1-PI3K-AKT signaling axis.
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