Evidence map›Paper›PMID 40794833›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.

Sarah Frail, Melissa Steele-Ogus, Jon Doenier, Solène L Y Moulin, Tom Braukmann, Shouling Xu, Ellen Yeh

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Genomes of NBMC genomics · 2026
    Article
  2. Review
  3. Review
  4. Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sarah Frail *Department of Biochemistry, Stanford School of Medicine, Stanford, CA 94305.ORCID 0000-0003-0718-3092
Melissa Steele-Ogus *Department of Pathology, Stanford School of Medicine, Stanford, CA 94305.ORCID 0000-0001-8143-1352
Jon DoenierDepartment of Biochemistry, Stanford School of Medicine, Stanford, CA 94305.ORCID 0009-0009-4576-0082
Solène L Y MoulinDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305.ORCID 0000-0002-7347-1247
Tom BraukmannDepartment of Biochemistry, Stanford School of Medicine, Stanford, CA 94305.
Shouling XuDepartment of Plant Biology, Carnegie Institution, Stanford, CA 94305.
Ellen YehDepartment of Pathology, Stanford School of Medicine, Stanford, CA 94305.ORCID 0000-0003-3974-3816

Funding

Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
MOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9M
Thermo Orbitrap Eclipse Tribrid with ETD and an Ultimate 3000 RSLCnano SystemS10OD030441 · OD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2022 to 2022
$600k
Burroughs Wellcome Fund (BWF) NAChan Zuckerberg Initiative (CZI) NAHHS | NIH (NIH) 5T32AI007328-32HHS | NIH (NIH) T32GM007276NIAID NIH HHS T32 AI007328NIGMS NIH HHS T32 GM007276NIH HHS S10 OD030441
6 · The paper itself

Abstract

Endosymbiotic gene transfer (EGT) and import of host-encoded proteins have been considered hallmarks of organelles necessary for stable integration of two cells. However, newer endosymbiotic models have challenged the origin and timing of such genetic integration during organellogenesis.

Indexed as

DiatomsGenome, PlastidOrganelle BiogenesisSymbiosisTransformation, GeneticBiological EvolutionCyanobacteriaGene Transfer, HorizontalMultigene FamilyNitrogen FixationOrigin of LifeProteomeProteomecyanobacteriadiatomendosymbiosisgenomeorganellogenesis

Identifiers

PMID40794833
PMCPMC12377750

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.