ReviewMilitary medicine2025
Molecular Mechanisms Underlying Burn-Injury Induced Pain: From Inflammation to Epigenetics.
Review in Military medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- [A compulsory course in clinical treatment of burn patients: pain and analgesia].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Cellular and molecular changes in the skin driving increased nociception and pain during burn injury and repair.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn modern warfare, blast and burn insults account for over half of combat injuries. Burn-injured Service Members represent one military patient population in need of a pain management regimen that involves optimal acute pain control, reduced chronic pain, and reduced risk of addiction. Burn pain is a significant clinical problem. The current standard of care can result in decreasing analgesia or the need for dosage escalation that incurs an increased risk of significant side effects. This review describes the current understanding of many important structures and mechanisms associated with burn pain, and these subjects provide promising targets for novel analgesics. MATERIALS AND
methodsAn independent literature retrieval was performed by all authors using a combination of search terms, including "burn" and "pain," alongside "glia," "receptors," "brain," "allodynia," "hyperalgesia," "central sensitization," "inflammation," and "tolerance." The search encompassed renowned reference repositories, namely PubMed (MEDLINE) and Scopus.
resultsBurn injuries are accompanied by complex pain originating after thermal insult, and this pain persists through treatment procedures like debridement, wound dressing, grafting, and wound closure. Understanding the molecular mechanisms that persist following burn injury is critical. This review highlights specific topics, including receptors and brain anatomy pertinent to pain, burn-induced allodynia and hyperalgesia, central sensitization, molecular signatures of burn-induced nociception and pain, and opioid analgesic tolerance.
conclusionsInterventions to accelerate burn injury healing and/or diminish the deleterious effects of dysregulated inflammatory and immune responses following severe burn are needed. Therefore, elucidating the underlying molecular mechanisms of burn-injury induced pain is of the utmost importance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.