Evidence map›Paper›PMID 40796268›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Na

Jakob Sauer, Jessica Marksteiner, Martin Hohenegger, Hannes Todt, Helmut Kubista, Christopher Dostal, Attila Kiss, Bruno K Podesser, Isabella Salzer, Xaver Koenig and 3 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. SGLT2 inhibitors to the rescue: restoring cardiac sodium channel membrane function in muscular dystrophy.American journal of physiology. Heart and circulatory physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jakob SauerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Jessica MarksteinerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Martin HoheneggerInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Hannes TodtDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1147-4370
Helmut KubistaDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Christopher DostalLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4961-6458
Attila KissLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4652-1998
Bruno K PodesserLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-4641-7202
Isabella SalzerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Xaver KoenigDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2423-4966
Anna Stary-WeinzingerDivision of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Karlheinz HilberDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-3033-0874
Oliver KudlacekInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Funding

Austrian Science Fund (FWF) P-35542-BAustrian Science Fund (FWF) P-35878-BAustrian Science Fund FWF P 35542Austrian Science Fund FWF P 35878
6 · The paper itself

Abstract

Diminished peak sodium current (

Indexed as

Benzhydryl CompoundsGlucosidesMuscular Dystrophy, DuchenneMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelSodium-Glucose Transporter 2 InhibitorsAction PotentialsAnimalsCells, CulturedHumansMaleMiceMice, Inbred C57BLMice, Inbred mdxPurkinje FibersRatsBenzhydryl CompoundsempagliflozinGlucosidesNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseScn5a protein, ratSodium-Glucose Transporter 2 Inhibitorsarrhythmiascardiomyocyte sodium currentsDuchenne muscular dystrophyempagliflozinpharmacochaperone

Identifiers

PMID40796268
PMCPMC7618122

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.