Evidence mapPaperPMID 40796291Full record

ReviewFEMS microbiology reviews2025

Mechanisms underlying alterations of the gut microbiota by exercise and their role in shaping ecological resilience.

Alex E Mohr, Núria Mach, Jamie Pugh, Gregory J Grosicki, Jacob M Allen, J Philip Karl, Corrie M Whisner

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Obesity and metabolic disease in migrants: a role for the gut microbiome?Frontiers in clinical diabetes and healthcare · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alex E MohrCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, United States.ORCID 0000-0001-5401-3702
Núria MachIHAP, Université de Toulouse, INRAE, ENVT, Toulouse, 31076, France.
Jamie PughSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, L3 5AH, United Kingdom.
Gregory J GrosickiBiodynamics and Human Performance Center, Georgia Southern University, Savannah, GA 31419, United States.
Jacob M AllenDepartment of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
J Philip KarlMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760, United States.
Corrie M WhisnerCollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, United States.

Funding

Interdisciplinary Systems-based Training for Precision NutritionT32DK137525 · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2025 to 2025
$499k
NIDDK NIH HHS T32 DK137525NIH HHS T32DK137525
6 · The paper itself

Abstract

The gut microbiota (GM) is a dynamic ecosystem intricately linked to human health, including metabolic, immune, endocrine, and gastrointestinal functions. Exercise is recognized as a significant modifier of this microbial ecosystem, yet the complexities of this relationship are underexplored. Here, we delve into the multifaceted interactions between structured physical activity and the GM, emphasizing the role of exercise-induced stressors in shaping microbial composition and function. Unique to our review, we discuss the acute effects of different forms of exercise-induced stress on the GM and explore how these responses may influence long-term adaptability, stability, and resilience. Furthermore, we address critical junctures in microbial dynamics leading to shifts between different stable states. Finally, we explore the implications of host-controlled factors such as diet, exercise training, and nutritional supplementation in modulating the microbial community in the gut to optimize athletic performance. We conclude that while the potential to harness the synergistic effects of exercise-induced stressors, dietary interventions, and microbial adaptations appears promising, current evidence remains preliminary, highlighting the need for additional targeted research to guide future strategies that manipulate the GM for optimal health and athletic performance.

Indexed as

ExerciseGastrointestinal MicrobiomeDietHumansacute stressathletegut–muscle axismicrobial ecologymicrobiomeprecision health

Identifiers

PMID40796291
PMCPMC12366553

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.