ArticleCell death & disease2025
Exosomes from liver progenitor cells carrying JAG1 activate notch signaling to promote liver regeneration in PVL rats.
Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- SIRT1 induces FOXO1/autophagy/NCOA4-induced ferroptosis and accelerates the progression of cerebral infarction by inhibiting the E2F1/NOTCH-1/YAP signaling pathway.Scientific reports · 2026Article
- Notch signaling in liver diseases: mechanistic insights and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- Research Progress on Mesenchymal Stem Cells-Derived Small Size Vesicles for the Treatment of Liver Diseases.International journal of nanomedicine · 2026Review
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Authors and funding
8 authors.
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Abstract
Studies have shown that extracellular vesicles play a crucial role in maintaining homeostasis in healthy individuals and influencing disease pathology in patients. However, the mechanisms by which exosomes facilitate liver regeneration following portal vein ligation (PVL) remain unclear. Our previous research highlighted the critical role of the Notch signaling pathway in liver regeneration after PVL. Nevertheless, the involvement of liver-derived exosomes in actively promoting regeneration through the YAP-Notch signaling pathway and their role in cell proliferation have not been fully explored. In this study, we demonstrate that exosomes from hypertrophic liver tissue can activate the YAP-Notch signaling pathway both in vitro and in vivo, thereby promoting liver regeneration after PVL. Specifically, we show that these exosomes carry JAG1, which activates Notch signaling in recipient cells, a process that is inhibited by JAG1 antibodies. Co-immunoprecipitation and mass spectrometry (Co-IP-MS) identified JAG1 interactors, confirming that ALG-2 plays a critical role in linking SEC31A and Alix to facilitate the intracellular transport and sorting of JAG1 onto exosomes. Additionally, we reveal that YAP induces hepatocyte reprogramming into Sox9
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