Evidence map›Paper›PMID 40796739›Full record

ArticleNature communications2025

Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants.

Sarah H Merkling, Elodie Couderc, Anna B Crist, Stéphanie Dabo, Josquin Daron, Natapong Jupatanakul, Myriam Burckbuchler, Thomas Vial, Odile Sismeiro, Rachel Legendre and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Vector competence acrossJournal of virology · 2026
    Review
  3. Article
  4. TheFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sarah H Merkling *Institut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.ORCID http://orcid.org/0000-0002-6823-4474
Elodie Couderc *Institut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.ORCID http://orcid.org/0000-0001-7508-8439
Anna B CristInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.
Stéphanie DaboInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.ORCID http://orcid.org/0000-0002-6275-0128
Josquin DaronInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.
Natapong JupatanakulInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.ORCID http://orcid.org/0000-0003-2326-4255
Myriam BurckbuchlerUniversité de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France.
Thomas VialInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.ORCID http://orcid.org/0000-0003-3347-7342
Odile SismeiroInstitut Pasteur, Digital Education Division, Education Department, Paris, France.
Rachel LegendreInstitut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France.ORCID http://orcid.org/0000-0002-5196-9431
Adrien PainInstitut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France.ORCID http://orcid.org/0000-0003-0467-1357
Hugo VaretInstitut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France.ORCID http://orcid.org/0000-0003-3980-4463
Davy JiolleInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France.
Diego AyalaMIVEGEC, Montpellier University, IRD, CNRS, Montpellier, France.ORCID http://orcid.org/0000-0003-4726-580X
Christophe PaupyMIVEGEC, Montpellier University, IRD, CNRS, Montpellier, France.ORCID http://orcid.org/0000-0002-7122-2079
Eric MaroisUniversité de Strasbourg, CNRS UPR9022, INSERM U1257, Strasbourg, France.ORCID http://orcid.org/0000-0003-4147-3747
Louis LambrechtsInstitut Pasteur, Université Paris Cité, CNRS UMR2000, Insect-Virus Interactions Unit, Paris, France. louis.lambrechts@pasteur.fr.ORCID http://orcid.org/0000-0001-5958-2138

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-LABX-62-IBEIDAgence Nationale de la Recherche (French National Research Agency) ANR-17-ERC2-0016-01Agence Nationale de la Recherche (French National Research Agency) ANR-18-CE35-0003-01
6 · The paper itself

Abstract

The mosquito Aedes aegypti is the primary vector for dengue virus (DENV), which infects millions of people annually. Variability in DENV susceptibility among wild Ae. aegypti populations is governed by genetic factors, but specific causal variants are unknown. Here, we identify a cytochrome P450-encoding gene (CYP4G15) whose genetic variants drive differences in DENV susceptibility in a natural Ae. aegypti population. CYP4G15 is transiently upregulated in DENV-resistant midguts, while knockdown increases susceptibility, and transgenic overexpression enhances resistance. A naturally occurring 18-base-pair promoter deletion reduces CYP4G15 expression and confers higher DENV susceptibility. The unexpected role of a cytochrome P450 in DENV susceptibility challenges the long-standing focus on canonical immune pathways and opens new avenues for understanding antiviral defense and DENV transmission in mosquitoes.

Indexed as

AedesCytochrome P-450 Enzyme SystemDengueDengue VirusInsect ProteinsMosquito VectorsPromoter Regions, GeneticAnimalsAnimals, Genetically ModifiedFemaleGenetic VariationCytochrome P-450 Enzyme SystemInsect Proteins

Identifiers

PMID40796739
PMCPMC12343897

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.