Evidence map›Paper›PMID 40796793›Full record

SynthesisScientific reports2025

Systematic review and meta-analysis of the impact of loss of consciousness on clinical outcomes in mild traumatic brain injury.

Jasmine Omair, Victoria Alkin, Vaitheesh Jaganathan, Martin F Bjurström, Doniel Drazin, Emily Sieg, Robert P Friedland, Maxwell Boakye, Nicholas Dietz

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jasmine OmairUniversity of Louisville School of Medicine, Louisville, KY, USA.
Victoria AlkinDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.
Vaitheesh JaganathanDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.
Martin F BjurströmDepartment of Surgical Sciences, Clinical Pain Research, Uppsala University, Uppsala, Sweden. martin.flores.bjurstrom@uu.se.
Doniel DrazinDepartment of Neurosurgery, Providence Regional Medical Center Everett, Everett, WA, USA.
Emily SiegDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.
Robert P FriedlandDepartment of Neurology, University of Louisville, Louisville, KY, USA.
Maxwell BoakyeDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.
Nicholas DietzDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While loss of consciousness (LOC) is a key factor in assessing head injuries, its impact on clinical outcomes, including persistent post-concussive symptoms, mental health disorders, quality of life, and neurodegeneration, remains unclear. This systematic review explores the association of LOC in Mild Traumatic Brain Injury (mTBI) with clinical outcomes such as mental health, quality of life, and risk of neurodegenerative diseases. Comprehensive systematic review methodology; two electronic databases (PubMed, Embase) were systematically searched from January 1990 to December 2024. Pooled odds ratios (OR) were obtained using a random effects model. A total of 595 studies were assessed with 30 trials meeting inclusion criteria. The presence of LOC is associated with worsened clinical outcomes including persistent post-concussive symptoms (OR 1.89, 95% CI: 1.59-2.25), post-traumatic stress disorder (OR 1.81, 95% CI: 1.54-2.12), depression (OR 2.69, 95% CI: 2.10-3.43), and overall health-related quality of life (OR 1.84, 95% CI: 1.49-2.26). These findings suggest that the role of LOC in the outcomes of mTBI supports a higher risk of poorer short and long-term outcomes. Future studies may investigate variation in post-mTBI sequelae among those with similar LOC timelines.

Indexed as

Brain ConcussionUnconsciousnessDepressionHumansPost-Concussion SyndromeQuality of LifeStress Disorders, Post-TraumaticClinical outcomesConcussionLoss of consciousnessTraumatic brain injury

Identifiers

PMID40796793
PMCPMC12343850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.