ReviewCell communication and signaling : CCS2025
Targeting cytokine and chemokine signaling pathways for enhancing chemo-sensitivity in colorectal cancer.
Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- The Red AlgaCurrent issues in molecular biology · 2026Article
- Chitosan/β-cyclodextrin nanocarriers enhance 5-fluorouracil efficacy against colorectal cancer via pH-responsive release and apoptosis modulation.Scientific reports · 2026Article
- Multifaceted Attack Networks of Artemisinin in Reversing Chemoresistance in Colorectal Cancer.Molecules (Basel, Switzerland) · 2026Review
- Enhanced mRNA Expression of Colonic IL-6 in Cronkhite-Canada Syndrome Bearing Colorectal Cancer.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemo-resistance is one of the main obstacles in the treatment of colorectal cancer. Many studies have been performed to identify the mechanisms associated with chemo-resistance in colorectal cancer cells, and it has been found that increasing the activity of ABC family transporters, enhancing DNA repair, weakening apoptosis, strengthening stemness, and EMT are among the most important of these mechanisms. Inflammation and cytokines have been linked to colorectal cancer, and there is even a type of colorectal cancer that is caused by chronic inflammation in patients with inflammatory bowel disease. However, the association between cytokines and chemo-resistance in colorectal cancer cells is not yet clear. Various studies have shown that chemotherapy drugs, by affecting the tumor microenvironment, can enhance the recruitment of some immune cells and the production of some cytokines. These cytokines have a variety of effects on various chemo-resistance mechanisms in colorectal cancer cells. Some of them can strengthen chemo-resistance and others weaken chemo-resistance. IL-6, TNFα, IFN, IL1, IL8, IL-17, IL-10, and IL-22 are among the most important cytokines whose effects on chemo-resistance mechanisms in colorectal cancer cells are known. In this article, we will have a comprehensive overview of the effects of these cytokines on chemo-resistance mechanisms in colorectal cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.