ArticleNature communications2025
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Routine MRI for opportunistic osteoporosis screening: diagnostic accuracy of vertebral bone quality and a novel femoral bone quality score compared with DXA.Skeletal radiology · 2026Article
- Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity.The Journal of endocrinology · 2026Article
- C-type lectin domain family 11 member A protects osteogenic differentiation of mouse embryonic osteoblast precursor cells against lipotoxicity by inhibiting oxidative stress.Cell stress & chaperones · 2026Article
- Optimal visceral adipose tissue thresholds that minimize risk for osteoporosis and/or diabetes in midlife women.Journal of the Endocrine Society · 2026Article
- Deep Learning for Analysis of Bone Marrow Adiposity: Breakthroughs from Recent Large-Scale Analyses in the UK Biobank.Current osteoporosis reports · 2026Review
- Poor Bone Health Associated with Reduced Cerebral Perfusion and Brain Volume in Older Adults.Diagnostics (Basel, Switzerland) · 2026Article
- The Multiscale Heterogeneity of Adipose Tissue in Health and Disease.Research (Washington, D.C.) · 2026Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. To identify its underlying genetic factors, we utilized a deep learning algorithm capable of quantifying bone marrow fat fraction (BMFF) in the vertebrae and proximal femur using magnetic resonance imaging data of over 38,000 UK Biobank participants. Genome-wide association analyses uncovered 373 significant BMFF-associated variants (P-value < 5 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.