Evidence map›Paper›PMID 40796990›Full record

ArticleInflammopharmacology2025

Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3/STAT3 signaling axis.

Shen Cao, Yuhan Wang, Yi Tai, Jing Han, Yanjin Zheng, Can Wang, Hong Xiang Zuo, Ming Yue Li, Yue Xing, Xuejun Jin and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shen Cao *Molecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Yuhan Wang *Affiliated Hospital of Yanbian University (Yanbian Hospital), Yanji, China.
Yi TaiMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Jing HanMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Yanjin ZhengMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Can WangMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Hong Xiang ZuoMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Ming Yue LiMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China.
Yue XingMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China. yuexing@ybu.edu.cn.
Xuejun JinMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China. xjjin@ybu.edu.cn.
Juan MaMolecular Medicine Research Center, College of Pharmacy, Ministry of Education Key Laboratory of Changbai Mountain Natural Resources and Functional Molecules), Yanbian University, Yanji, 133002, Jilin Province, China. majuan@ybu.edu.cn.ORCID http://orcid.org/0000-0001-6121-2486

Funding

National Natural Science Foundation of China No.82304834The Jilin Province Science and Technology Development Plan 20240602086RCThe Jilin Province Science and Technology Development Plan YDZJ202201ZYTS169The Jilin Province Science and Technology Development Plan YDZJ2022101ZYTS180The Jilin Province Science and Technology Development Plan YDZJ202301ZYTS457
6 · The paper itself

Abstract

Ulcerative colitis (UC) is an inflammatory disease characterized by lifelong involvement and a complex pathogenesis. Due to the limitations of current treatment modalities, there remains a pressing need to discover new medications for the management of UC. Cucurbitacin B (CuB) is a tetracyclic triterpenoid derived from Lagenaria siceraria (Molina) Standl., exhibiting pharmacological activities including hepatoprotective, anti-inflammatory, and anti-tumor properties. In this study, we conducted a comprehensive evaluation of the anti-inflammatory activity of CuB in both DSS-induced experimental colitis in vivo and macrophage models in vitro. Our results indicate that CuB exerts an anti-inflammatory effect by regulating the assembly of the NLRP3 inflammasome and the activation of p-STAT3 via ZNF70, thereby reducing the release of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Such results indicate that CuB can effectively prevent the development of UC and offer new insights for its management.

Indexed as

ColitisNLR Family, Pyrin Domain-Containing 3 ProteinSTAT3 Transcription FactorTriterpenesAnimalsAnti-Inflammatory AgentsColitis, UlcerativeCytokinesDextran SulfateDisease Models, AnimalInflammasomesMaleMiceMice, Inbred C57BLRAW 264.7 CellsSignal TransductionAnti-Inflammatory Agentscucurbitacin BCytokinesDextran SulfateInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorTriterpenesCucurbitacin BNLRP3 inflammasomeSTAT3Ulcerative colitisZNF70

Identifiers

PMID40796990

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.