ReviewJournal of cancer survivorship : research and practice2025
Cannabinoids for the prevention of chemotherapy-induced nausea and vomiting in oncological therapy: a systematic review.
Review in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antiproliferative Effects of Cannabinoids and Cisplatin in Cervical Cancer Cells.Cancer reports (Hoboken, N.J.) · 2026Article
- Does Cannabinoid Use Reduce Opioid Utilization Among Patients with Gastrointestinal Cancer? Evidence from Epic COSMOS.Cancers · 2026Article
- [Therapeutic indications in lawsuits seeking medical Cannabis in Brazil: a cross-sectional study in light of scientific evidence].Cadernos de saude publica · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCannabinoids are compounds that occur naturally in cannabis plants. The objective of this systematic review was to provide an overview of the existing evidence regarding the use of cannabinoids for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients.
methodsA systematic literature search was conducted in June 2024 in five electronic databases (Embase, Cochrane, PsychInfo, CINAHL, and Medline) to identify studies examining the utilization, efficacy, and potential adverse effects of cannabinoid-based therapy in cancer patients.
resultsA total of 32 studies comprising 1889 patients suffering from different cancer types were included in the systematic review. Cannabinoid-based therapy involved the oral administration of defined and approved cannabis preparations. Of the 22 studies comparing cannabinoid-based CINV management to now outdated antiemetic therapies, 12 found a significant benefit of cannabinoids in CINV management, and eight out of nine studies comparing cannabinoids to placebo observed such a benefit. Only one of the 32 studies with a risk of bias compared cannabinoids to guideline-based therapy with a 5-HT3 receptor antagonist, an NK1 receptor antagonist, and dexamethasone and demonstrated a benefit of cannabinoids in reducing nausea and vomiting, but the therapy was associated with cannabinoid-related side effects.
conclusionWith only one study complying with modern antiemetic standards and considering the risks of side effects, clinical evidence to recommend cannabinoids for the management of CINV is deemed insufficient. IMPLICATIONS FOR CANCER SURVIVORS: Cancer patients suffering from CINV might find alleviation using cannabinoids, but heterogenous results and side effects prevent clinical recommendation.
Indexed as
Identifiers
40797063What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.