SynthesisInternational journal of colorectal disease2025
Efficacy of non-pharmacological interventions for the restoration of postoperative intestinal motility of patients with colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Multidisciplinary Approach to Enhanced Recovery After Surgery in Colorectal Cancer: An Updated Narrative Review.Cureus · 2026Review
- Intestinal Rehabilitation Plan for Patients with Colorectal Cancer During the Perioperative Period: An Evidence Synthesis.Journal of multidisciplinary healthcare · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAs a major indicator for rehabilitation progress, the restoration of postoperative intestinal motility of patients with colorectal cancer (CRC) is highly publicized. Various non-pharmacological interventions (NPIs) are helpful for bowel recovery. This study aims to evaluate the efficacy of NPIs in enhancing the restoration of postoperative intestinal motility.
methodsSystematic searches were conducted in the Cochrane Library, PubMed, EBSCO, and Embase databases from inception to March 2025, with language restrictions to English. Eligible studies that quantified the effect of NPIs for the restoration of postoperative intestinal motility of patients with colorectal cancer were selected. The primary outcomes were time to first flatus and time to first defecation. The secondary outcomes were time to tolerate fluid food or solid food and length of hospital stay (LOS). Statistical analysis was performed in Review Manager 5.4, Stata v.15.1, and R 4.4.3 software.
resultsA total of 23 randomized controlled trials (RCTs) involving 3264 patients and 11 NPIs were selected. Gum chewing significantly shortened the time to first flatus (MD = - 5.88, 95% CI - 10.33 to - 1.43; I
conclusionDietary treatments are characterized by their low cost, diverse taste profiles, and lack of dependence on medical settings, making them more amenable to large-scale clinical practice promotion. Particularly, 100 mg caffeine, decaffeinated coffee, and gum chewing are worth paying attention to and recommending. For physical treatments, the limited number of studies and restricted application countries, coupled with higher costs and more stringent implementation requirements, pose significant challenges; therefore, they should be approached with caution. Given the limited evidence currently available, clinical decision-making regarding NPIs should integrate these findings with a focused consideration of the clinical setting, patient needs and preferences, and professional judgment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.