Evidence map›Paper›PMID 40797182›Full record

Trial reportBMC nephrology2025

Effects of sodium bicarbonate therapy on cognitive and cerebrovascular function in midlife and older adults with chronic kidney disease: a pilot randomized trial.

Fangning Gu, Zhiying You, Nell Hawkins, Rachael Reddin, Rahaf Hamour, Allison Shapiro, Christina Coughlan, Douglas Seals, Seth Furgeson, Angelina Dixon and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04600323 (Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04600323 early_phase1completednot on this map

Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD

TypeinterventionalSponsorUniversity of Colorado, DenverRan2021 to 2023Enrolled34ConditionsMetabolic Acidosis, Chronic Kidney Disease, Cognitive DysfunctionArmsSodium Bicarbonate Tablets, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fangning GuDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Zhiying YouDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Nell HawkinsDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Rachael ReddinDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Rahaf HamourDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Allison ShapiroDepartment of Pediatrics, Section of Pediatric Endocrinology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Christina CoughlanDepartment of Neurology, University of Colorado Alzheimer's and Cognition Center (CUACC), University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Douglas SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Seth FurgesonDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Angelina DixonDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Kristen L NowakDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Jessica KendrickDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Jessica.Kendrick@cuanschutz.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetabolic acidosis may create a pathway to cognitive impairment in chronic kidney disease (CKD) by contributing to cerebrovascular dysfunction. Trials examining the effect of sodium bicarbonate (NaHCO

methodsWe conducted a randomized, double-blind, placebo-controlled pilot study examining the effect of 12 months of NaHCO

results33 patients completed the study. After 12 months of treatment with NaHCO

conclusionsAlthough there were trends supporting a role for sodium bicarbonate in having an effect on cognitive function, this was not significant in this underpowered study. A larger study is recommended.

trial registrationClinicaltrials.gov (NCT04600323) on 10/19/2020.

Indexed as

AcidosisCerebrovascular CirculationCognitionCognitive DysfunctionRenal Insufficiency, ChronicSodium BicarbonateAgedAged, 80 and overDouble-Blind MethodFemaleHumansMaleMiddle AgedMiddle Cerebral ArteryPilot ProjectsUltrasonography, Doppler, TranscranialSodium BicarbonateChronic kidney diseaseCognitionMetabolic acidosisSodium bicarbonate

Identifiers

PMID40797182
PMCPMC12341264

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.