Observational studyMedicine2025
The relationship between hematological parameters such as eosinophil-basophil levels, eosinophil-to-basophil ratio, monocyte-to-basophil ratio, and the coronary slow flow phenomenon.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary slow flow phenomenon (CSFP) is characterized by delayed coronary artery filling in the absence of significant obstructive coronary artery disease. It typically presents with angina-like chest pain and is defined by delayed opacification of the coronary arteries despite the absence of obstructive lesions. Although the pathophysiology of CSFP remains poorly understood, microvascular dysfunction, endothelial impairment, and systemic inflammation have been proposed as contributing factors. Hematological parameters, such as eosinophil and basophil counts, along with the eosinophil-to-basophil ratio (EBR) and monocyte-to-basophil ratio (MBR), have emerged as potential indicators of inflammation and cardiovascular pathology. This study aimed to investigate the association between these hematological markers and CSFP to enhance understanding and guide the development of diagnostic and therapeutic strategies. In this retrospective study, eosinophil, basophil, and monocyte counts, as well as derived ratios (EBR and MBR), were analyzed in 233 patients with CSFP and 229 controls who underwent coronary angiography but had normal coronary arteries. Blood samples were processed using an automated hematology analyzer. Group comparisons were performed using the independent samples t-test and Mann-Whitney U test (P < .05). Spearman correlation and logistic regression analyses were conducted to assess associations among variables. There was no statistically significant difference in the median age between the CSFP group (56.0 [IQR: 15.0]) and the control group (57.0 [IQR: 15.0]; P = .905). The CSFP group consisted predominantly of males (161 males, 72 females), whereas the control group had a higher proportion of females (152 females, 77 males), with a statistically significant difference in sex distribution (P < .001). Patients with CSFP exhibited significantly higher monocyte counts (P < .001), eosinophil counts (P = .012), EBR (P = .010), and MBR (P = .008) than controls. This study demonstrated significant differences in hematological parameters between patients with CSFP and controls. These findings suggest that specific hematological indices, particularly immune cell ratios, could serve as accessible, cost-effective biomarkers for CSFP. Further studies are needed to clarify their mechanistic roles and therapeutic relevance.
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