Evidence map›Paper›PMID 40799514›Full record

ArticleLife medicine2025

A framework of biomarkers for visual system aging: a consensus statement by the Aging Biomarker Consortium.

Aging Biomarker Consortium, Chao Ma, Boxin Geng, Yangqing Zhang, Shan Li, Ruiyang Li, Wenben Chen, Si Wang, Weiqi Zhang, Jing Qu and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Aging Biomarker Consortium
Chao MaBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Boxin GengBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Yangqing ZhangBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Shan LiBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Ruiyang LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
Wenben ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
Si WangAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Weiqi ZhangChina National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Jing QuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Yun FengDepartment of Ophthalmology, Peking University First Hospital, Beijing 100034, China.
Qingfeng LiangBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Kangxin JinBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Yonghao GuDepartment of Ophthalmology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China.
Wenru SuDepartment of Ophthalmology, State Key Laboratory of Visual Science Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Xuxiang ZhangDepartment of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100037, China.
Wenjuan ZhuangDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750011, China.
Jihong WuDepartment of Opthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Zhaoyang WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
Shengping HouBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
Jiaxu HongDepartment of Ophthalmology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Honghua YuGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Biao YanDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Mingguang HeThe Hong Kong Polytechnic University, Hong Kong 999077, China.
Fan LvState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325041, China.
Guang-Hui LiuState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID https://orcid.org/0000-0001-9289-8177
Gang PeiCollaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Qingjiong ZhangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.ORCID https://orcid.org/0000-0001-7508-848X
Tian XueDepartment of Ophthalmology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Zi-Bing JinBeijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital Medical University, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.ORCID https://orcid.org/0000-0003-0515-698X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The visual system is essential for human perception, converting light signals into electrical impulses and transmitting them to the brain to process environmental information. As individuals age, their physiological functions gradually decline, leading to age-related vision impairment that significantly impacts the quality of life in elderly individuals. China is home to the world's largest aging population and faces significant challenges in combating visual system aging through effective treatments and interventions. In response to this challenge, the Aging Biomarker Consortium (ABC) of China has developed a consensus statement on biomarkers of visual system aging by integrating cutting-edge global research and synthesizing evidence-based medicine with clinical expertise. This consensus provides a multi-dimensional evaluation framework encompassing functional, morphological, and molecular biomarkers. Validated biomarkers for each domain are recommended not only to facilitate the early detection of vision changes but also to provide insights into the progression of age-related ocular diseases. By advancing this initiative, ABC aims to revolutionize visual health management in aging societies, ultimately improving outcomes for elderly populations in China and globally.

Identifiers

PMID40799514
PMCPMC12342612

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.