Association between dietary fiber intake and post-stroke depression among US women: insights from the NHANES 2005-2018 cross-sectional study.

Background: Few studies have established a link between the dietary fiber intake (DFI) and post-stroke depression (PSD). Drawing on data collected in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018, this investigation systematically examined the association between DFI and PSD in US women. Methods: A cross-sectional study was conducted using data from female participants in the NHANES from 2005 to 2018. The inclusion criteria comprised complete data on DFI, stroke history, and depression status. Multivariate logistic regression models were utilized to evaluate the association between DFI and the risk of PSD among the female population. To assess model validity, the Hosmer-Lemeshow test was performed to examine calibration, and a receiver operating characteristic (ROC) curve was constructed to measure discriminative ability. A restricted cubic spline (RCS) was employed to examine the correlations. Furthermore, subgroup analyses and interactions were also conducted to evaluate the stability of the relationship between DFI and PSD among different subgroups. Results: Among 13,143 screened female participants, 105 were diagnosed with PSD. The multivariate logistic regression model, after adjusting for all potential covariates, demonstrated that the odds ratio (OR) for the association between DFI and PSD was 0.92 [95% confidence interval (CI): 0.88-0.96; Conclusion: The findings suggest a non-linear negative association between DFI and PSD risk among US women.