Evidence map›Paper›PMID 40799582›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic mechanisms of resistance to targeted KRAS inhibition.

Bianca J Diaz, Max Kops, Sara Bernardo, Henri Schmidt, Elizabeth Grankowsky, Adrian Vega, Chen Zhang, Matthew Bott, Maria Skamagki, Aidan Tomlinson and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bianca J DiazSandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY.
Max KopsSandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY.
Sara BernardoSandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY.
Henri SchmidtDepartment of Computer Science, Princeton University, Princeton, NJ.
Elizabeth GrankowskySandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY.
Adrian VegaSandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY.
Chen ZhangDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
Matthew BottDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Maria SkamagkiDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Aidan TomlinsonRevolution Medicines, Inc., Redwood City, CA.
Nicole A VitaRevolution Medicines, Inc., Redwood City, CA.
Alyna KattiRevolution Medicines, Inc., Redwood City, CA.
Mark P LabrecqueRevolution Medicines, Inc., Redwood City, CA.
Ida AronchikRevolution Medicines, Inc., Redwood City, CA.
Mallika SinghRevolution Medicines, Inc., Redwood City, CA.
Lukas E DowSandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY.ORCID 0000-0001-7048-1418

Funding

Interrogating the role of mutant KRAS allelic imbalance and co-mutated genes in targeted therapy response of NSCLCF31CA261061 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DIAZ, BIANCA · 2021 to 2024
$189k
NCI NIH HHS F31 CA261061
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40799582
PMCPMC12340830

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.