ArticleAlzheimer's & dementia (New York, N. Y.)
Health and Aging Brain Study-Health Disparities (HABS-HD) methods and partner characteristics.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non-Hispanic White cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Article
- Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies.The Lancet. Neurology · 2026Article
- Bilingualism and cognitive aging in ethnically diverse older adults: cross-sectional and longitudinal evidence from Health and Aging Brain Study-Health Disparities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Unfavorable Social Determinants of Health Are Associated with Lower Cognitive Performance in Non-Hispanic Black Men - The HABS-HD Study.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Chronic stress, social support, and domain-specific cognitive decline in HABS-HD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Interleukin-6 is associated with white matter hyperintensities and cognition independent of Alzheimer's disease plasma biomarkers-HABS-HD.Journal of Alzheimer's disease : JAD · 2026Article
- Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers.Annals of neurology · 2026Article
- Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Alzheimer's disease blood-based biomarkers and visit-to-visit blood pressure variability: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2026Article
- Orthogonal Contributions of Genetic, Clinical, and Social Determinants of Health Risk Burdens on Alzheimer's Disease Pathophysiology.medRxiv : the preprint server for health sciences · 2026Article
- Race and Ethnicity, Hypertension, and Neuroimaging Markers of Brain Aging: A Causal Mediation Analysis in the HABS-HD Study.Neurology · 2026Article
- Feynman-Kac Reweighted Schrödinger Bridge Matching for Surface-based Tau PET Harmonization.ArXiv · 2026Article
- Spatiotemporal dynamics of tau extent and load increase in Alzheimer's disease across four longitudinal cohorts.Nature aging · 2026Article
- Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diffusion-based generative fiber orientation restoration from severe signal loss in diffusion-weighted MRI.Medical image analysis · 2026Article
- Evaluation of physical functioning as a marker of brain imaging outcomes in a multiethnic community-based cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Predicting Preclinical Cognitive Decline Using Plasma P-tau217 andmedRxiv : the preprint server for health sciences · 2026Article
- Substituting blood-based biomarkers for imaging measures in Alzheimer's disease studies: implications for sample size and bias.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Contrasting associations of diastolic blood pressure with plasma amyloid, tau, and neurodegeneration biomarkers in the Health and Aging Brain Study-Health Disparities (HABS-HD).Journal of Alzheimer's disease : JAD · 2026Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
introductionThe Health and Aging Brain Study-Health Disparities (HABS-HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of the cohort baseline characteristics and outlines the study methodology.
methodsWe analyzed available data from
resultsThe characteristics of the cohort revealed significant groupwise differences in age, education, sex, and cognitive diagnosis. Higher rates of cognitive impairment (mild cognitive impairment [MCI] and dementia) were found in NHB and Hispanic compared to NHW partners, despite the latter group being older. There were also higher rates of hypertension and diabetes among NHB and Hispanic compared to NHW partners. Differences were also found across many plasma (A/T[N]) biomarkers and select neuroimaging measures, including meta-region of interest and white matter hyperintensities. Positron emission tomography amyloid positivity rates (but not tau positivity) were found to differ, with higher rates observed among NHW (15% amyloid positivity) compared to NHB (3%) partners. Groups also differed by select SDoH factors, including household income, insurance, having a health-care provider, and Area Deprivation Index. All cognitive measures also revealed groupwise differences. DISCUSSION: The baseline cohort characteristics for HABS-HD reveal significant group differences spanning demographic, medical, cognitive, and biological factors (including A/T[N] biomarkers), which are all critical to understand as they relate to aging and age-related diseases. Highlights: The Health and Aging Brain Study-Health Disparities (HABS-HD) cohort baseline characteristics and study methodology were provided.Cohort characteristic differences were found across demographic factors, including age, education, sex, and cognitive diagnosis across the representative groups.Biomarkers for amyloid/tau/neurodegeneration spanning blood and neuroimaging were shown to differ as well across cohort groups.Positivity rates for amyloid positron emission tomography were lower for non-Hispanic Black partners in the cohort compared to non-Hispanic White partners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.