ArticleJournal of the Endocrine Society2025
From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study.
Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study.Journal of the Endocrine Society · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Context: Hypothyroidism's role in coronary heart disease (CHD) and its link with lipid metabolism is debated. Our study aims to clarify the causal relationship between hypothyroidism and CHD, focusing on the potential mediating effects of lipid profiles. Objective: To assess the causal effect of hypothyroidism on the development of CHD and examine the mediating role of lipid profiles through Mendelian randomization (MR). Methods: We conducted MR tests using genome-wide association study data of 500 000 participants of European ancestry from FinnGen and UK Biobank, respectively. Bidirectional MR tests were utilized to confirm causality, and the results of an inverse variance weighted method served as the main analysis. Weighted median, MR-Egger, and MR-Pleiotropy Residual Sum and Outlier methods were utilized as sensitivity analyses to validate our findings. Results: We found genetically predicted hypothyroidism increased the risk of CHD by 7.8% [odds ratio (OR) = 1.078, 95% confidence interval (CI) 1.026-1.134, Conclusion: Our findings suggested a causal link between hypothyroidism and increased CHD risk, likely mediated through changes in HDL-C and apolipoprotein A-I levels. This highlights the importance of monitoring lipid levels in hypothyroid patients and calls for further research to explore these relationships and their implications for prevention and treatment strategies.
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