ArticleNeurophotonics2025
Brief disruptions in capillary flow result in rapid onset of hypoxia.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Microvascular dysfunction and aberrant network activity drive reduced brain oxygenation in a mouse tauopathy model.Research square · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Significance: Capillaries are the critical site of vascular exchange with the local tissue, with continuous flow to meet the brain's unique and steep energetic demands. However, transient stalls in capillary flow have been observed and at elevated levels in preclinical models of disease. Systematic measurements have not been made to quantify the acute effects of individual capillary stalls on local oxygen. Aim: We aim to quantify oxygen dynamics around capillary stalls as they occur Approach: We use high-resolution two-photon phosphorescent lifetime microscopy (2PLM) to monitor capillary flux and Results: All stalls cause rapid drops in intra-capillary oxygen that likely extend to local tissue based on estimates using the erythrocyte-associated transient (EAT). This includes a subset of capillaries, which reach critically hypoxic levels (<10 mmHg), which could not be predicted by the capillaries' normal flux and oxygen levels, nor local vessel density or proximity to diving arterioles and venules. Conclusion: Our findings indicate that a subset of capillary stalls reach extremely low local oxygen, resulting in transient hypoxia in the surrounding tissue. This reveals a new potential pathological mechanism due to stalled capillary flow.
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Registered trials
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