Evidence map›Paper›PMID 40800491›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2024

Leveraging multi-echo EPI to enhance BOLD sensitivity in task-based olfactory fMRI.

Ludwig Sichen Zhao, Clara U Raithel, M Dylan Tisdall, John A Detre, Jay A Gottfried

Erratum issuedAbstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. TE-aware state analysis and evolution in dynamic network connectivity.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Robust-tedana: An automated denoising pipeline for multi-echo fMRI data.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ludwig Sichen ZhaoDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States.
Clara U RaithelDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
M Dylan TisdallDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
John A DetreDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Jay A GottfriedDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Funding

Behavioral and Neural Substrates of Odor-Guided Navigation in the Human BrainU01DC019405 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI GOTTFRIED, JAY A · 2023 to 2025
$1.4M
Behavioral and Neural Substrates of Odor-Guided Navigation in the Human BrainR01DC019405 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI Jay A Gottfried · 2022 to 2026
$924k
NIDCD NIH HHS R01 DC019405NIDCD NIH HHS U01 DC019405
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) usingblood-oxygenation-level-dependent (BOLD) contrast relies on gradient echoecho-planar imaging (GE-EPI) to quantify dynamic susceptibility changesassociated with the hemodynamic response to neural activity. However, acquiringBOLD fMRI in human olfactory regions is particularly challenging due to theirproximity to the sinuses where large susceptibility gradients induce magneticfield distortions. BOLD fMRI of the human olfactory system is furthercomplicated by respiratory artifacts that are highly correlated with eventonsets in olfactory tasks. Multi-echo EPI (ME-EPI) acquires gradient echo dataat multiple echo times (TEs) during a single acquisition and can leverage signalevolution over the multiple echo times to enhance BOLD sensitivity and reduceartifactual signal contributions. In the current study, we developed an ME-EPIacquisition protocol for olfactory task-based fMRI and demonstrated significantimprovement in BOLD signal sensitivity over conventional single-echo EPI(1E-EPI). The observed improvement arose from both an increase in BOLD signalchanges through a

Indexed as

ME-ICAmulti-echo EPIolfactionsusceptibility artifactstask-based fMRI

Identifiers

PMID40800491
PMCPMC12315737

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.