Evidence map›Paper›PMID 40800503›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2024

Heritability and genetic contribution analysis of structural-functional coupling in human brain.

Wei Dai, Zhengwu Zhang, Peihan Song, Heping Zhang, Yize Zhao

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei DaiDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, United States.
Zhengwu ZhangDepartment of Statistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Peihan SongDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, United States.
Heping ZhangDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, United States.
Yize ZhaoDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, United States.

Funding

An integrative Bayesian approach for linking brain to behavioral phenotypeR01EB034720 · NIBIB · YALE UNIVERSITY · PI R Todd Constable, Yize Zhao · 2023 to 2026
$2.4M
Novel integrative imaging genetics analysis for Alzheimer's disease riskand progressionRF1AG068191 · NIA · YALE UNIVERSITY · PI ZHAO, YIZE · 2021 to 2021
$1.9M
Novel integrative imaging genetics analysis for Alzheimer's disease riskand progressionR01AG068191 · NIA · YALE UNIVERSITY · PI ZHAO, YIZE · 2024 to 2025
$1.2M
NIA NIH HHS R01 AG068191NIA NIH HHS RF1 AG068191NIBIB NIH HHS R01 EB034720
6 · The paper itself

Abstract

The flow of functional connectivity (FC) is thought to be supported by white matter structural connectivity (SC). While research on the correlations between SC and FC (SC-FC coupling) has progressed, the genetic implications of SC-FC coupling have not been thoroughly examined. Traditionally, SC-FC coupling investigations utilize predefined atlases. Here, we adopted an atlas-free SC-FC coupling built on the high-resolution white surface (the interface of white matter and gray matter) to uncover common genetic variations. Leveraging data from the Human Connectome Project, we demonstrated considerable heritability in areas within the early and intermediate visual cortex and across dorsal-attention, language, and somatomotor functional networks. We detected 334 genetic loci (spanning 234 cytogenetic bands) linked to SC-FC coupling (P < 1.26 × 10

Indexed as

functional connectivityGWASheritabilitystructural connectivitystructural connectivity-functional connectivity (SC-FC) coupling

Identifiers

PMID40800503
PMCPMC12290780

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.