ArticleThe American statistician2025
An Example to Illustrate Randomized Trial Estimands and Estimators.
Article in The American statistician, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutics for Alcohol-Associated Liver Disease.Annual review of pharmacology and toxicology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recently, the International Conference on Harmonisation finalized an estimand framework for randomized trials that was adopted by regulatory bodies worldwide. The framework introduced five strategies for handling post-randomization events; namely the treatment policy, composite variable, while on treatment, hypothetical and principal stratum estimands. We describe an illustrative example to elucidate the difference between these five strategies for handling intercurrent events and provide an estimation technique for each. Specifically, we consider the intercurrent event of treatment discontinuation and introduce potential outcome notation to describe five estimands and corresponding estimators: 1) an intention-to-treat estimator of the total effect of a treatment policy; 2) an intention-to-treat estimator of a composite of the outcome and remaining on treatment; 3) a per-protocol estimator of the outcome in individuals observed to remain on treatment; 4) a g-computation estimator of a hypothetical scenario that all individuals remain on treatment; and 5) a principal stratum estimator of the treatment effect in individuals who would remain on treatment under the experimental condition. Additional insight is provided by defining situations where certain estimands are equal, and by studying the while on treatment strategy under repeated outcome measures. We highlight relevant causal inference literature to enable adoption in practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.